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A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy

Pizzano M, Vereertbrugghen A, Martínez J, Bernatowiez J, Aguilar DV, Sabbione F, Keitelman I, Giordano M, Trevani A, Fuentes F, Galletti J.   +10 more
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Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain

Neuroscience, 2006
Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels have been proposed to act as metabotropic and ionotropic receptors, respectively, for two classes of endogenous polyunsaturated fatty acid amides, the acylethanolamides and the acyldopamides.
Luigia Cristino, Vincenzo Di Marzo, David Baker   +2 more
exaly   +3 more sources

Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 – 2014)

Expert Opinion on Therapeutic Patents, 2015
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin. Since TRPV1 acts as an integrator of painful stimuli, TRPV1 antagonists can be used as promising therapeutics for new types of analgesics.This review article covers the patents ...
Yoonji Lee, Minghua Cui, Jeewoo Lee
exaly   +3 more sources

Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity [PDF]

Circulation Research, 2007
We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR.
Zhang, Li Li, Yan Liu, Dao, Ma, Li Qun, Luo, Zhi Dan, Cao, Ting Bing, Zhong, Jian, Yan, Zhen Cheng, Wang, Li Juan, Zhao, Zhi Gang, Zhu, Shan Jun, Schrader, Mark, Thilo, Florian, Zhu, Zhi Ming, Tepel, Martin   +13 more
exaly   +3 more sources

Polymodal Transient Receptor Potential Vanilloid Type 1 Nocisensor

Advances in protein chemistry and structural biology, 2016
Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an attempt to comprehend the piquancy and pain mechanism of the archetypal vanilloids, transient receptor potential vanilloid (TRPV) 1 was discovered.
Minghua, Cui, Vijayakumar, Gosu, Shaherin, Basith, Sunhye, Hong, Sun, Choi   +4 more
openaire   +2 more sources

Transient receptor potential vanilloid type 1 and pain development

Current Opinion in Pharmacology, 2012
Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up ...
PALAZZO, Enza, LUONGO, Livio, DE NOVELLIS, Vito, ROSSI, Francesco, MARABESE, Ida, MAIONE, Sabatino   +5 more
openaire   +3 more sources

Agonist-Dependent Potentiation of Vanilloid Receptor Transient Receptor Potential Vanilloid Type 1 Function by Stilbene Derivatives

Molecular Pharmacology, 2012
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Understanding mechanisms for functional modulation of TRPV1 has important implications.
Xuan, Zhang, Xiao-Na, Du, Guo-Hong, Zhang, Zhan-Feng, Jia, Xing-Juan, Chen, Dong-Yang, Huang, Bo-Yi, Liu, Hai-Lin, Zhang   +7 more
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Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis

American Journal of Obstetrics and Gynecology, 2010
We sought to investigate the expression and localization of oxytocin receptor (OTR) and transient receptor potential vanilloid type 1 (TRPV1) in women with and without adenomyosis.Ectopic and homologous eutopic endometrium from 50 women with adenomyosis and endometrium from 18 women without adenomyosis were used for immunohistochemical analysis of OTR ...
Jichan Nie, Xishi Liu, Sun-Wei Guo
exaly   +3 more sources

A patent review of transient receptor potential vanilloid type 1 modulators (2014–present)

Expert Opinion on Therapeutic Patents, 2020
Introduction: Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel with high permeability to calcium, which is widely expressed in the central nervous system (CNS) and peripheral nervous system. Since the TRPV1 was molecularly cloned more than 20 years ago, a series of research activities have been carried out on the ...
Mengkang, Gao, Yusui, Wang, Lanqi, Liu, Zhenrui, Qiao, Lin, Yan   +4 more
openaire   +2 more sources