Results 201 to 210 of about 23,801 (234)

Upregulation of Transient Receptor Potential Vanilloid Type-1 Receptor Expression in Oral Lichen Planus

Neuroimmunomodulation, 2009
<i>Objectives:</i> Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. Its etiology is still unclear. Neurogenic components might contribute to the inflammatory process. The oral mucosa is richly innervated by sensory fibers.
Agnes, Bán, Rita, Marincsák, Tamás, Bíró, Anikó, Perkecz, Eva, Gömöri, Katalin, Sándor, István Balázs, Tóth, Agnes, Bánvölgyi, János, Szolcsányi, Erika, Pintér   +9 more
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Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type-1 Ion Channel

2014
The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (> -42 degrees C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently,
Nagy, Istvan, Friston, Dominic, Valente, João Sousa, Perez, Jose Vicente Torres, Andreou, Anna P.   +4 more
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Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels

Neuroscience & Biobehavioral Reviews, 2014
The Transient Receptor Potential Vanilloid Type-1 (TRPV1) was first characterized in primary afferent fibers as a receptor for capsaicin (the pungent ingredient of chili peppers). Later on, this cation-permeable ion channel was also described in the central nervous system, where its main putative endogenous ligand is N-arachidonoyl ethanolamide (an ...
D.C. Aguiar, F.A. Moreira, A.L. Terzian, M.V. Fogaça, S.F. Lisboa, C.T. Wotjak, F.S. Guimaraes   +6 more
openaire   +3 more sources

Molecular Structure of Transient Receptor Potential Vanilloid Type 1 Ion Channel (TRPV1)

Current Pharmaceutical Biotechnology, 2011
Elaboration of the structure of TRPV1 and its functional relationship with channel activity is a work in progress, with much remaining to be done before the structure-function relationship of TRPV1 is comprehensively elicited. The result is that the present state of knowledge can reasonably be described as a patch-work of insightful data where major ...
Laszlo, Urban, John P M, White, Istvan, Nagy   +2 more
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The Potential of Transient Receptor Potential Vanilloid Type 1 Channel Modulators for the Treatment of Pain

Journal of Medicinal Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function

Journal of Neuroscience Research, 2014
Transient receptor potential vanilloid type 1 (TRPV1) channels are capable of detecting and integrating noxious stimuli and play an important role in nociceptor activation and sensitization. It has been demonstrated that oxidizing agents are capable of positively modulating (sensitizing) the TRPV1 channel.
Kevin P, Carlin, Gang, Wu, Aniket, Patel, Gregg, Crumley, Victor I, Ilyin   +4 more
openaire   +2 more sources

A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine

European Journal of Pharmacology, 2012
The present study investigated the influence of transient receptor vanilloid type 1 (TRPV1) channel agonist (capsaicin) and antagonist (capsazepine) either alone or in combination with traditional antidepressant drug, fluoxetine; or a serotonin hydroxylase inhibitor, para-chlorophenylalanine; or a glutamate N-methyl-D-aspartate (NMDA) receptor agonist,
Shyamshree S S, Manna, Sudhir N, Umathe
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Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1)

European Journal of Pain, 2020
AbstractBackgroundPUVA (psoralen UVA) therapy is used to treat a variety of skin conditions, such as vitiligo psoriasis, eczema and mycosis fungoides, but it is frequently accompanied by phototoxicity leading to burning pain, itch and erythema.MethodsWe used a combination of calcium and reactive oxygen species (ROS) imaging, patch clamp and ...
Alexandru, Babes, Tatjana I, Kichko, Tudor, Selescu, Alexandra, Manolache, Cristian, Neacsu, Lisa, Gebhardt, Peter W, Reeh   +6 more
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Increased transient receptor potential vanilloid type 1 (TRPV1) channel expression in hypertrophic heart

Biochemical and Biophysical Research Communications, 2010
The aim of this study was to compare the expression of transient receptor potential vanilloid type 1 (TRPV1) channels in hypertrophic hearts from transgenic mice showing overexpression of the catalytic subunit alpha of protein phosphatase 2A alpha (PP2Ac alpha) with wild-type mice and with TRPV1-/- mice. Transcripts of TRPV1, matrix metalloproteinase 9
Thilo, Florian, Liu, Ying, Schulz, Nico, Gergs, Ulrich, Neumann, Joachim, Loddenkemper, Christoph, Gollasch, Maik, Tepel, Martin   +7 more
openaire   +3 more sources

Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

Blood Coagulation & Fibrinolysis, 2012
Capsaicin is an agonist of transient receptor potential vanilloid type 1 (TRPV1), in which it can act as a neuronal stimulant and result in nociception. Capsaicin also affects a variety of nonneuronal tissues, in which its mechanisms of action are less certain.
Scott W, Mittelstadt, Richard A, Nelson, Jerome F, Daanen, Andrew J, King, Michael E, Kort, Philip R, Kym, Nathan L, Lubbers, Bryan F, Cox, James J, Lynch   +8 more
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