Results 41 to 50 of about 23,501 (259)
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On the translation-proper of toponyms in Romanian translations at the beginning of the 19th century [PDF]
Diacronia, 2018 The translation of certain toponyms that had not yet been assimilated to the Romanian language at the beginning of the 19th century represented a real challenge for translators at that time.
Dinu Moscal
doaj +1 more source
„Idegen szülöttet […] csempész a családi név alá”
Névtani Értesítő, 2021 “Smuggling an illegitimate child […] into the family” Name and names in literary approaches to translation The study formulates hypotheses for a more extensive historical examination of the connections and relations of names and translation ...
ILDIKÓ JÓZAN
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Proper Names: Translating Reference and Application
Journal of the College of Basic Education, 2022 غالبًا ما تُعتبر ترجمة أسماء العلم عملية آلية بسيطة للترجمة من لغة إلى أخرى ، نظرًا لوجهة النظر القائلة بأن الأسماء الصحيحة ليست سوى تسميات تُستخدم لتعريف شخص أو شيء حتى لا تتطلب ترجمتها على أنها ليس لها معنى ولا تحمل حواس.قد يكون هذا الافتراض خاطئًا لأن معظم الأسماء الصحيحة ليست مجرد تحديد للتسميات بل لها نوع من المعاني أو المعاني الخاصة بها والتي ...
openaire +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Névtani Értesítő, 2015 The aim of this study is to present the problems that may be raised by the translation of proper names on different levels of context, and the methods with which translators can solve these issues.
Vermes, Albert
doaj
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source