Results 1 to 10 of about 10,052 (217)

Improving Clinical Diagnosis of Transmissible Spongiform Encephalopathies in Sheep: Which Signs Are Important? [PDF]

Animals
Scrapie is a notifiable transmissible spongiform encephalopathy (TSE) in sheep that relies on clinical examinations for reporting suspects. A short examination protocol was used in 1002 sheep to define clinical markers suggestive of scrapie.
Timm Konold, Laura J. Phelan
doaj   +2 more sources

Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine [PDF]

Emerging Infectious Diseases, 2008
The route of transmission of most naturally acquired transmissible spongiform encephalopathy (TSE) infections remains speculative. To investigate urine as a potential source of TSE exposure, we used a sensitive method for detection and quantitation of ...
Luisa Gregori, Gabor G. Kovacs, Irina Alexeeva, Herbert Budka, Robert G. Rohwer   +4 more
doaj   +2 more sources

Rapid Typing of Transmissible Spongiform Encephalopathy Strains with Differential ELISA [PDF]

Emerging Infectious Diseases, 2008
The bovine spongiform encephalopathy (BSE) agent has been transmitted to humans, leading to variant Creutzfeldt-Jakob disease. Sheep and goats can be experimentally infected by BSE and have been potentially exposed to natural BSE; however, whether BSE ...
Stéphanie Simon, Jérôme Nugier, Nathalie Morel, Hervé Boutal, Christophe Créminon, Sylvie L. Benestad, Olivier Andréoletti, Frédéric Lantier, Jean-Marc Bilheude, Muriel Feyssaguet, Anne-Gaëlle Biacabe, Thierry Baron, Jacques Grassi   +12 more
doaj   +2 more sources

CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis [PDF]

BioImpacts, 2022
Introduction: The limited efficacy of BCG (bacillus Calmette–Guérin) urgently requires new effective vaccination approaches for the control of tuberculosis. Poly lactic-co-glycolic acid (PLGA) is a prevalent drug delivery system.
Zhengmin Liang, Miaoxuan Li, Jiamin Ni, Tariq Hussain, Jiao Yao, Yinjuan Song, Yiduo Liu, Haoran Wang, Xiangmei Zhou   +8 more
doaj   +1 more source

Transmissible spongiform encephalopathies

Journal of the American Veterinary Medical Association, 2008
Abstract Transmissible spongiform encephalopathies (TSEs), or prion diseases, are invariably fatal neurodegenerative diseases of humans and animals. TSEs are believed to be caused by neuronal accumulation of a protease-resistant abnormal conformer of a host-encoded protein known as prion protein.
James J, Sejvar, Lawrence B, Schonberger, Ermias D, Belay   +2 more
  +8 more sources

PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

Cell Death and Disease, 2022
A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li, Mengyu Lai, Xixi Zhang, Zhiping Li, Dongming Yang, Mengyang Zhao, Dongdong Wang, Zhixin Sun, Sharjeel Ehsan, Wen Li, Hongli Gao, Deming Zhao, Lifeng Yang   +12 more
doaj   +1 more source

Implications of gut microbiota dysbiosis and metabolic changes in prion disease

Neurobiology of Disease, 2020
Evidence of the gut microbiota influencing neurodegenerative diseases has been reported for several neural diseases. However, there is little insight regarding the relationship between the gut microbiota and prion disease. Here, using fecal samples of 12
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang   +12 more
doaj   +1 more source

Transmissible Spongiform Encephalopathies

New England Journal of Medicine, 1997
The transmissible spongiform encephalopathies are caused by infectious agents but usually present as genetic or sporadic disorders. The nature of the infectious agents is not known. In 1986 a new transmissible spongiform encephalopathy, which was called bovine spongiform encephalopathy or “mad cow disease,” was described in Britain.1 In 1996 the ...
V, Moennig, J, Fritzemeier
  +7 more sources

Immunoregulatory and Antimicrobial Activity of Bovine Neutrophil β-Defensin-5-Loaded PLGA Nanoparticles against Mycobacterium bovis

Pharmaceutics, 2020
Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis complex imposing a high zoonotic threat to human health. The limited efficacy of BCG (Bacillus Calmette–Guérin) and upsurges of drug-resistant tuberculosis require new effective
Zhengmin Liang, Yiduo Liu, Xingya Sun, Jingjun Lin, Jiao Yao, Yinjuan Song, Miaoxuan Li, Tianlong Liu, Xiangmei Zhou   +8 more
doaj   +1 more source

Effects of Flaxseed and Multi-Carbohydrase Enzymes on the Cecal Microbiota and Liver Inflammation of Laying Hens

Animals, 2021
Background: The use of wheat and flaxseed to produce omega-3 (ω-3) enriched poultry meat and eggs is very popular in the world. However, wheat and flaxseed contain some anti-nutritional factors (ANFs), and enzymes are usually used to alleviate the ...
Mazhar Hussain Mangi, Tariq Hussain, Muhammad Suhaib Shahid, Naveed Sabir, Muhammad Saleem Kalhoro, Xiangmei Zhou, Jianmin Yuan   +6 more
doaj   +1 more source