Results 11 to 20 of about 10,052 (217)

Strain Traits of Intracranially Administered L-Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys. [PDF]

Microbiol Immunol
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Hagiwara K, Shibata H, Tobiume M, Sato Y, Ohto K, Okabayashi S, Nakano N, Horiuchi M, Ono F.   +8 more
europepmc   +2 more sources

Experimental Bovine Spongiform Encephalopathy in Squirrel Monkeys: The Same Complex Proteinopathy Appearing after Very Different Incubation Times

Pathogens, 2022
Incubation periods in humans infected with transmissible spongiform encephalopathy (TSE) agents can exceed 50 years. In humans infected with bovine spongiform encephalopathy (BSE) agents, the effects of a “species barrier,” often observed when TSE ...
Pedro Piccardo, Juraj Cervenak, Wilfred Goldmann, Paula Stewart, Kitty L. Pomeroy, Luisa Gregori, Oksana Yakovleva, David M. Asher   +7 more
doaj   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., Jacobs, J.G., Keulen, L.J.M., van, Langeveld, J.P.M., Sauer, M., Tang, Y.   +5 more
core   +2 more sources

Detection of Cell-Free Mitochondrial DNA in Cerebrospinal Fluid of Creutzfeldt-Jakob Patients

Frontiers in Neurology, 2019
Background: The current diagnosis method for Creutzfeldt-Jakob disease (CJD) is post-mortem examination, so early detection of CJD has been historically problematic. Auxiliary detection of CJD based on changes in levels of components of the cerebrospinal
Jie Li, Yuhan Duan, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Xixi Zhang, Mengyu Lai, Zhiling Guan, Dongming Yang, Xiaoqian Wu, Hongli Gao, Huafen Zhao, Qi Shi, Lifeng Yang   +13 more
doaj   +1 more source

TSE pathogenesis in cattle and sheep [PDF]

, 2008
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A., Keulen, L.J.M., van, Zijderveld, F.G., van   +2 more
core   +3 more sources

Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis

Cells, 2019
Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases.
Naveed Sabir, Tariq Hussain, Yi Liao, Jie Wang, Yinjuan Song, Muhammad Shahid, Guangyu Cheng, Mazhar Hussain Mangi, Jiao Yao, Lifeng Yang, Deming Zhao, Xiangmei Zhou   +11 more
doaj   +1 more source

Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling

Frontiers in Microbiology, 2020
Mycobacterium bovis is the causative agent of bovine tuberculosis, has been identified a serious threat to human population. It has been found that sodium butyrate (NaB), the inhibitor of histone deacetylase, can promote the expression of cathelicidin ...
Kai Zhang, Tariq Hussain, Tariq Hussain, Jie Wang, Mengying Li, Wenjia Wang, Xiaojing Ma, Yi Liao, Jiao Yao, Yinjuan Song, Zhengmin Liang, Xiangmei Zhou, Lihua Xu   +12 more
doaj   +1 more source

Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study [PDF]

, 2008
The aim of this study was to analyze molecular features of protease-resistant prion protein (PrPres) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status.
Jacobs, J.G., Langeveld, J.P.M., Polak, M.P., Zmudzinski, J.F.   +3 more
core   +1 more source

Emerging infectious diseases: coping with uncertainty [PDF]

, 2009
The world’s scientific community must be in a state of constant readiness to address the threat posed by newly emerging infectious diseases. Whether the disease in question is SARS in humans or BSE in animals, scientists must be able to put into action ...
Cummings, L
core   +1 more source

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection

BMC Infectious Diseases, 2019
Background Mycobacterium bovis (M. bovis) is the principal causative agent of bovine tuberculosis; however, it may also cause serious infection in human being.
Jie Wang, Tariq Hussain, Kai Zhang, Yi Liao, Jiao Yao, Yinjuan Song, Naveed Sabir, Guangyu Cheng, Haodi Dong, Miaoxuan Li, Jiamin Ni, Mazhar Hussain Mangi, Deming Zhao, Xiangmei Zhou   +13 more
doaj   +1 more source