Results 31 to 40 of about 1,247,898 (402)

Clonal expansion shapes the human V\u3b41T cell receptor repertoire. [PDF]

, 2017
Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not ...
Dieli, F., Meraviglia, S.
core   +1 more source

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance

JCI Insight, 2022
Dominant infectious tolerance explains how brief tolerance-inducing therapies result in lifelong tolerance to donor antigens and “linked” third-party antigens, while recipient sensitization and ensuing immunological memory prevent the successful ...
Michael S. Andrade, James S. Young, Jared M. Pollard, Dengping Yin, Maria-Luisa Alegre, Anita S. Chong   +5 more
doaj   +1 more source

The changing immunology of organ transplantation [PDF]

, 1995
The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft.
Demetris AJ, Lu L, Lu L, Murase N, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Steinman RM, Streilein JW, Thomas JM   +10 more
core   +1 more source

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

Frontiers in Immunology, 2017
Cells expressing IDO suppress innate and adaptive immunity to promote tolerance by catabolizing the amino acid tryptophan (Trp) and other indole compounds.
Andrew L. Mellor, Henrique Lemos, Lei Huang   +2 more
doaj   +1 more source

Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

JCI Insight, 2021
The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent inhibitory pathway involved in immune regulation and is a potential therapeutic target in transplantation. In this study, we show that overexpression of PD-1 on T cells (PD-
Thiago J. Borges, Naoka Murakami, Isadora T. Lape, Rodrigo B. Gassen, Kaifeng Liu, Songjie Cai, Joe Daccache, Kassem Safa, Tetsunosuke Shimizu, Shunsuke Ohori, Alison M. Paterson, Paolo Cravedi, Jamil Azzi, Peter T. Sage, Arlene H. Sharpe, Xian C. Li, Leonardo V. Riella   +16 more
doaj   +1 more source

The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells

Frontiers in Immunology, 2018
BackgroundT follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such ...
Elizabeth F. Wallin, Danika L. Hill, Danika L. Hill, Michelle A. Linterman, Kathryn J. Wood   +4 more
doaj   +1 more source

NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant

JCI Insight, 2021
CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival ...
Harry Pickering, Subha Sen, Janice Arakawa-Hoyt, Kenichi Ishiyama, Yumeng Sun, Rajesh Parmar, Richard S. Ahn, Gemalene Sunga, Megan Llamas, Alexander Hoffmann, Mario Deng, Suphamai Bunnapradist, Joanna M. Schaenman, David W. Gjertson, Maura Rossetti, Lewis L. Lanier, Elaine F. Reed, CMV Systems Immunobiology Group   +17 more
doaj   +1 more source

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

Gut, 2023
Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations ...
L. Lopetuso, S. Deleu, L. Godny, V. Petito, P. Puca, Federica Facciotti, H. Sokol, G. Ianiro, L. Masucci, M. Abreu, I. Dotan, S. Costello, A. Hart, T. Iqbal, S. Paramsothy, M. Sanguinetti, S. Danese, H. Tilg, F. Cominelli, T. Pizarro, A. Armuzzi, G. Cammarota, A. Gasbarrini, S. Vermeire, F. Scaldaferri   +24 more
semanticscholar   +1 more source

Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver grafts [PDF]

Clinical and Molecular Hepatology
Background/Aims The shortage of donor liver hinders the development of liver transplantation. This study aimed to clarify the poor outcomes of functionally marginal liver grafts (FMLs) and provide evidence for the improvement of ischemia-free liver ...
Shuai Wang, Xiaohong Lin, Yunhua Tang, Yichen Liang, Min Zhang, Zhonghao Xie, Yiwen Guo, Yuqi Dong, Qiang Zhao, Zhiyong Guo, Dongping Wang, Xiaoshun He, Weiqiang Ju, Maogen Chen   +13 more
doaj   +1 more source

T-bet+CD27+CD21– B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants

JCI Insight, 2021
Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components controlling them ...
Kevin Louis, Elodie Bailly, Camila Macedo, Louis Lau, Bala Ramaswami, Alexander Chang, Uma Chandran, Douglas Landsittel, Xinyan Gu, Geetha Chalasani, Adriana Zeevi, Parmjeet Randhawa, Harinder Singh, Carmen Lefaucheur, Diana Metes   +14 more
doaj   +1 more source