JCI Insight, 2021 Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components controlling them ...
Kevin Louis +14 more
doaj +1 more source
Transplantation tolerance from a historical perspective [PDF]
, 2001 Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation, organ engraftment was accomplished first in humans, and was thought for many years to
Starzl, TE, Zinkernagel, RM
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IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
The Journal of Clinical Investigation, 2022 Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ...
Gaelen K. Dwyer +10 more
doaj +1 more source
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
JCI Insight, 2023 Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding ...
Isaac Rosado-Sánchez +8 more
doaj +1 more source
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
JCI Insight, 2023 Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized.
Hengcheng Zhang +12 more
doaj +1 more source
On the crossroad between tolerance and posttransplant lymphoma. [PDF]
, 1997 The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core +1 more source
Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. [PDF]
, 2017 BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested ...
Ardehali, Abbas +15 more
core +2 more sources
Computational Models for Transplant Biomarker Discovery. [PDF]
, 2015 Translational medicine offers a rich promise for improved diagnostics and drug discovery for biomedical research in the field of transplantation, where continued unmet diagnostic and therapeutic needs persist.
Sarwal, Minnie M, Wang, Anyou
core +4 more sources
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function
JCI Insight, 2023 Regulatory T cells (Tregs) have potential for the treatment of autoimmune diseases and graft rejection. Antigen specificity and functional stability are considered critical for their therapeutic efficacy.
Xiaoqian Ma +12 more
doaj +1 more source
Memory NK cell features exploitable in anticancer immunotherapy [PDF]
, 2019 Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone +5 more
core +2 more sources