Results 11 to 20 of about 122,409 (259)
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity
Immunological Medicine, 2021 Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and ...
Agustinus Darmadi Hariyanto +2 more
doaj +1 more source
CLEC5a-directed bispecific antibody for effective cellular phagocytosis
mAbs, 2022 While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Although the antitumor efficacy of immune checkpoint blockade (ICB) has been proved in colorectal cancer (CRC), the results are unsatisfactory, presumably owing to the presence of tryptophan metabolism enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and ...
Rongjie Zhang +8 more
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Regulation of T cell differentiation by the AP-1 transcription factor JunB
Immunological Medicine, 2021 JunB, a component of the activator protein-1 (AP-1) transcription factor, is known to exhibit an important role in bone formation and bone marrow cell proliferation. During T helper type 2 (Th2) cell differentiation, JunB contributes to the regulation of
Takaharu Katagiri +3 more
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Mathematical modeling of tumor-immune system interactions: the effect of rituximab on breast cancer immune response [PDF]
, 2021 tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8$^+$ T cells, CD4$^+$ T ...
arxiv +1 more source
OncoImmunology, 2019 Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination.
Hester J. Scheffer +9 more
doaj +1 more source
The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story
Microorganisms, 2019 The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng +3 more
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LKB1 Positively Regulates Dendritic Cell-induced T Cell Immunity and Suppresses Tumor Development [PDF]
Iranian Journal of Immunology, 2023 Background: The functions of dendritic cells (DCs) are influenced by their intracellular metabolism, in which liver kinase B1 (LKB1) plays an important role.
Wenjie Zhang +6 more
doaj +1 more source
Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis
Frontiers in Pharmacology, 2021 It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin +4 more
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CO-evaluation of Immunhistochemical PD-L1 and FOXP3 Expressions in Breast Cancer
Forbes Tıp Dergisi, 2023 Objective: Breast cancer is the most common cancer among women and is the second most frequent cause of cancer-related deaths worldwide. The aim of this study was to determine the prognostic values of PD-L1 expression in breast cancers and to detect the ...
Özge KAYA KORKMAZ +3 more
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