Results 11 to 20 of about 275,584 (397)
Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. [PDF]
Nature, 2019 Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
Cadilha, Bruno L +16 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Immunosuppressive Foxp3-expressing regulatory T cells (Tregs) in tumor tissues are assumed to be clonally expanding via recognizing tumor-associated antigens.
Yujiro Kidani +41 more
openalex +3 more sources
Gut microbes, 2023 Background With increasing knowledge about the gut – bone axis, more studies for treatments based on the regulation of postmenopausal osteoporosis by gut microbes are being conducted.
Mengyu Guo +10 more
openalex +2 more sources
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Cellular & Molecular Immunology, 2023 Balanced immunity is pivotal for health and homeostasis. CD4^+ helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens.
Junying Wang, Xingqi Zhao, Y. Wan
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Immunosuppressive Tregs constitutively express CTLA-4, an immune checkpoint receptor. Addressing the role of CTLA-4 in Treg-suppressive function, we show that Treg-expressed CTLA-4, even in the absence of its cytoplasmic portion, promoted ...
Murat Tekguc +4 more
semanticscholar +1 more source
Annual Review of Immunology, 2016 The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. It has become increasingly clear that the immune system has a second major function: the maintenance of organismal homeostasis. Foxp3+CD4+regulatory T cells (Tregs) are important contributors to both of these critical activities,
Marisella, Panduro +2 more
openaire +2 more sources
Lipid signalling enforces Treg cell functional specialization in tumours
Nature, 2021 Regulatory T cells (Treg cells) are essential for immune tolerance1, but also drive immunosuppression in the tumour microenvironment2. Therapeutic targeting of Treg cells in cancer will therefore require the identification of context-specific mechanisms ...
S. A. Lim +11 more
semanticscholar +1 more source
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors
Nature, 2021 Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T ...
R. Zappasodi +23 more
semanticscholar +1 more source
Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases
International Journal of Molecular Sciences, 2023 Regulatory T cells (Tregs) and T helper 17 cells (Th17) are two CD4+ T cell subsets with antagonist effects. Th17 cells promote inflammation, whereas Tregs are crucial in maintaining immune homeostasis.
Rony Thomas, Sai Qiao, Xi Yang
semanticscholar +1 more source
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases [PDF]
Frontiers in Immunology, 2020 Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells. The ICOS signaling pathway endows Tregs with increased generation, proliferation, and survival abilities.
Dan-Yang Li +3 more
openaire +3 more sources