Results 251 to 260 of about 212,475 (307)

JAK inhibitor tofacitinib alleviates secretory dysfunction and Th17/Treg imbalance in a Sjögren's disease murine model. [PDF]

Ann Med
Lin Y, Ou Y, Su J, Xu J, Liu C, He K, Zhou L, Wu D, Chen J.   +8 more
europepmc   +1 more source

Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Single‐cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

NLRP3 inflammasome regulates Th17/Treg cell balance in experimental autoimmune myocarditis. [PDF]

Biochem Biophys Rep
Su L, Qu N, Chen L, Lin Y, Mo H, Huang Y.   +5 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Beyond Conventional Transcriptional Regulation Function: FOXP3 as an Integrative Hub for Chromatin Interactions and Protein Complexes in Immune Regulation. [PDF]

Biology (Basel)
Chang H, Wang Y, Gao L, Zheng SJ.
europepmc   +1 more source

CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD. [PDF]

Respir Res
Dabo AJ, Geraghty P, Evgrafov O, Campos M, Hadas E, Kim BH, Potash MJ, Volsky DJ, Foronjy RF.   +8 more
europepmc   +1 more source

Context-dependent roles of sex hormone signaling in controlling visceral adipose tissue Treg heterogeneity and clonal expansion. [PDF]

J Immunol
Elkins C, Zhang J, Ye C, Moll S, Weitzmann MN, Li C.   +5 more
europepmc   +1 more source

Transcription factor Etv3 controls the tolerogenic function of dendritic cells. [PDF]

Science
Adams NM, Martinez-Krams D, Esteva E, Ra AC, Alexiou AI, Jin H, Yun TJ, Tellaoui RS, Mudianto T, Vollmer E, Novikova E, Tan Y, Huntley W, Krichevsky O, Dolgalev I, Izmirly P, Buyon JP, Moreira AL, Lund AW, Reizis B.   +19 more
europepmc   +1 more source

L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis. [PDF]

Microbiome
Ma PJ, Li M, Hu WT, Yang D, Liang YK, Chen L, Wang X, Pan Y, Wang Y.   +8 more
europepmc   +1 more source