Results 61 to 70 of about 212,475 (307)
OncoImmunology, 2019 Preclinical modeling and gene expression analyses have yielded distinct observations for the role of immune checkpoint, IDO1, in glioblastoma (GBM). Accordingly, our recent work differs with Garg et al.
Lijie Zhai +11 more
doaj +1 more source
The Effect of Alantolactone on the Development of Multiple Sclerosis
Proceedings, 2019 Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating neurodegenerative disease targeting the central nervous system. The pathogenesis of MS is an immune mediated process involving innate and adaptive immune system components.
Mustafa Cakir +3 more
doaj +1 more source
Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis
Frontiers in Pharmacology, 2021 It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin +4 more
doaj +1 more source
Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. [PDF]
, 2018 Cell-to-cell communication networks have critical roles in coordinating diverse organismal processes, such as tissue development or immune cell response. However, compared with intracellular signal transduction networks, the function and engineering
Altschuler, Steven J +2 more
core +2 more sources
Th17/Treg Imbalance and Atherosclerosis [PDF]
Disease Markers, 2020 Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity.
Xin He, Bo Liang, Ning Gu
openaire +2 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury
Journal of Inflammation Research, 2021 Min Zhou,1,* Yadi Zhang,2,* Rui Tang,1 Haiyan Liu,1 Min Du,1 Zhi Gao,1 Zongshu Ji,1 Haoshu Fang3 1Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei,
Zhou M +7 more
doaj
The Effect of Schisandrin B on the Development of Multiple Sclerosis
Proceedings, 2019 Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating neurodegenerative disease targeting the central nervous system. The pathogenesis of MS is a process of innate and adaptive immune system components.
Mustafa Cakir +3 more
doaj +1 more source
G-bundles, isomonodromy and quantum Weyl groups [PDF]
, 2002 First an `irregular Riemann-Hilbert correspondence' is established for meromorphic connections on principal G-bundles over a disc, where G is any connected complex reductive group. Secondly, in the case of poles of order two, isomonodromic deformations
Boalch, Philip
core +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source