Results 1 to 10 of about 191,176 (260)

The role of Treg cells in colorectal cancer and the immunotherapy targeting Treg cells. [PDF]

Front Immunol
Colorectal cancer (CRC) is among the most prevalent and lethal cancers globally, accounting for approximately 10% of all cancer cases and deaths. Regulatory T (Treg) cells, which accumulate in CRC tissue, suppress anti-tumor immune responses and facilitate tumor progression.
Yu H, Yang R, Li M, Li D, Xu Y.
europepmc   +4 more sources

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung, A Merlo, Ana Maria Waaga-Gasser, Andreas Rosenwald, C Loddenkemper, Christoph-Thomas Germer, E Sato, Eva Meier, F Ichihara, FA Sinicrope, FL Greene, H Groux, H Lu, H Suzuki, H Tao, HL Weiner, Igor Tsaur, J Shimizu, JD Fontenot, Jun Li, LM Ebert, M Viguier, Maria Lazariotou, Martin Gasser, Martin Grimm, ME Winerdal, Mia Kim, MJ Sack, N Chaput, N Hiraoka, N Kobayashi, P Correale, P Salama, P Yu, Roman Blaheta, S Hinz, S Ladoire, S Onizuka, T Alvaro, Tanja Grimmig, TL Whiteside, Uwe Heemann, V Karanikas, W Zou, WH Wang, WS Lee   +45 more
core   +14 more sources

Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cells [PDF]

, 2016
Recently, we demonstrated elevated numbers of CD4(+) Foxp3(+) regulatory T (Treg) cells in Plasmodium yoelii‐infected mice contributing to the regulation of anti‐malarial immune response. However, it remains unclear whether this increase in Treg cells is
Abel, S., Buer, J., Hansen, W., Hose, M., Hutzler, M., Kehrmann, J., Matuschewski, K., Tatura, R., Ueffing, K., Westendorf, A.   +9 more
core   +1 more source

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]

, 2015
Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace, Alastair Watson, Anika Fischer, Atreya, Babyatsky, Baumgart, Canavan, Caroline Voskens, Christoph Becker, Clemens Neufert, Danese, Desreumaux, Dustin, Egawa, Fantini, Feagan, Fuss, Gerlach, Gerold Schuler, Ghosh, Haddad, Hamann, Hesterberg, Hoshino, Imke Atreya, Jovani, Kanai, Kempster, Kim, Ley, Li, Macdonald, Markus F Neurath, Matsuzaki, Maul, Neurath, Neurath, Nguyen, Nourshargh, Oki, Papadakis, Picarella, Podolsky, Pryde, Raja Atreya, Rocío López-Posadas, Rott, Rutgeerts, Sandborn, Sandborn, Sebastian Zundler, Shultz, Simon Hirschmann, Strober, Thomas, Tidswell, Timo Rath, Van Assche, Vermeire, Villablanca, Wang, Weninger, Wirtz, Wyant, Wyant   +64 more
core   +1 more source

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. [PDF]

, 2019
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
Cadilha, Bruno L, Carrizosa, Esteban, Di Pilato, Mauro, Kim, Edward Y, Ligorio, Matteo, Mani, Vinidhra, Marangoni, Francesco, Medoff, Benjamin D, Mempel, Thorsten R, Misale, Sandra, Nasrallah, Mazen N, Prüßmann, Jasper N, Seruggia, Davide, Usmani, Shariq M, Villani, Alexandra-Chloe, Warner, Ross D, Zappulli, Valentina   +16 more
core   +2 more sources

Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. [PDF]

, 2008
Different functions have been attributed to natural regulatory CD4+CD25+FOXP+ (Treg) cells during malaria infection. Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites ...
Belanger, B, Cambos, M, Jacques, A, Roulet, A, Scorza, T   +4 more
core   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]

, 2016
MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann, Chang, Chong, Clambey, Cobb, Dang, Dardalhon, Elyaman, Filipowicz, Gerlach, Goswami, Goswami, Goswami, Haraguchi, He, Jabeen, Kaelin, Keith, Kohlhaas, Lewis, Licona-Limón, Lu, Lu, Lukashev, McNamee, Muljo, Nakatsukasa, Noelle, Nowak, Pua, Purwar, Schmitt, Shi, Singh, Staudt, Veldhoen, Yao, Zhou   +37 more
core   +2 more sources

Treg cells promote plaque regression [PDF]

Nature Reviews Cardiology, 2020
A new study shows that regulatory T cells have essential roles in atherosclerotic plaque regression by promoting the resolution of plaque inflammation through suppression of macrophage and T cell pro-inflammatory responses and induction of a pro-resolving macrophage phenotype.
openaire   +2 more sources

Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]

, 2011
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core   +1 more source