TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]
, 2018 A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L +4 more
core +1 more source
Circulating gluten-specific FOXP3 + CD39 + regulatory T cells have impaired suppressive function in patients with celiac disease [PDF]
, 2017 Background Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in patients with celiac disease has been well characterized, the role of regulatory T (Treg ...
Anderson, Robert P. +14 more
core +1 more source
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
, 2020 Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A. +11 more
core +1 more source
Throwing Treg cells off balance [PDF]
Nature Reviews Cancer, 2019 Di Pilato et al. selectively modulated the function of regulatory T (Treg) cells in tumours by targeting the CARMA1–BCL10–MALT1 (CBM) signalosome complex in only a fraction of Treg cells and showed that this was sufficient to impede tumour growth and prime the tumour microenvironment for immune checkpoint blockade.
openaire +2 more sources
Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression [PDF]
, 2015 The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).
Cahn, Pedro +13 more
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Supporting children with genetic syndromes in the classroom: the example of 22q deletion syndrome [PDF]
, 2013 An increasing number of children are likely to have a known genetic cause for their special educational needs. One such genetic condition is 22q11.2 deletion syndrome (22qDS), a genetic syndrome associated with early speech and language difficulties ...
Reilly, C, Stedman, L
core +1 more source
Eos, Goddess of Treg Cell Reprogramming [PDF]
Immunity, 2013 Under certain conditions, Sharma et al. (2013) show in this issue of Immunity that a subpopulation of Foxp3+ regulatory T cells loses expression of the transcription factor Eos and develops into Foxp3+ T helper cells that facilitate priming of naive CD8+ T cells.
Rieder, Sadiye Amcaoglu +1 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. [PDF]
, 2018 Cell-to-cell communication networks have critical roles in coordinating diverse organismal processes, such as tissue development or immune cell response. However, compared with intracellular signal transduction networks, the function and engineering
Altschuler, Steven J +2 more
core +2 more sources