Results 81 to 90 of about 130,982 (298)

Short‐chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 478-490, March 2025.
Abstract Objective An alteration in the composition of the intestinal microbiota has been observed in patients with multiple sclerosis (pwMS) with respect to healthy controls (HC). Microorganism‐derived metabolites such as short‐chain fatty acids (SCFA) have been suggested to play a role in the disease.
Maria Inmaculada Dominguez‐Mozo, Daniel López‐Mecández, Luisa María Villar, Lucienne Costa‐Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova‐Peño, Inés González‐Suárez, María Luisa Martínez‐Ginés, Jose Manuel García‐Domínguez, Estefanía García‐Calvo, Andrés Machuca‐Marcos, Jose Luis Luque‐Garcia, María Angel Garcia‐Martinez, Rafael Arroyo, Roberto Alvarez‐Lafuente   +18 more
wiley   +1 more source

Accumulation of Regulatory T Cells in Triple Negative Breast Cancer Can Boost Immune Disruption

Cancer Management and Research, 2021
Asmaa M Zahran,1 Omnia El-Badawy,2 Lamiaa M Kamel,3 Amal Rayan,4 Khalid Rezk,5 Mona H Abdel-Rahim2 1Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; 2Department of Medical Microbiology and Immunology ...
Zahran AM, El-Badawy O, Kamel LM, Rayan A, Rezk K, Abdel-Rahim MH   +5 more
doaj  

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Mathematical Modelling of Allergy and Specific Immunotherapy: Th1-Th2-Treg Interactions [PDF]

arXiv, 2010
Regulatory T cells (Treg) have recently been identified as playing a central role in allergy and during allergen-specific immunotherapy. We have extended our previous mathematical model describing the nonlinear dynamics of Th1-Th2 regulation by including Treg cells and their major cytokines.
arxiv  

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source

TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity. [PDF]

PLoS ONE, 2013
Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor (TCR).
Go Muto, Hitoshi Kotani, Taisuke Kondo, Rimpei Morita, Sanae Tsuruta, Takashi Kobayashi, Hervé Luche, Hans Joerg Fehling, Matthew Walsh, Yongwon Choi, Akihiko Yoshimura   +10 more
doaj   +1 more source

Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease [PDF]

arXiv, 2013
Acute Respiratory Distress Syndrome (ARDS) is a very severe syndrome leading to respiratory failure and subsequent mortality. Sepsis is one of the leading causes of ARDS. Thus, extracellular bacteria play an important role in the pathophysiology of ARDS. Overactivated neutrophils are the major effector cells in ARDS.
arxiv  

Metabolic Reprogramming of Cancer‐Associated Fibroblasts: Transforming Tumor Accomplices into Immunotherapeutic Allies

Advanced Functional Materials, Volume 35, Issue 13, March 25, 2025.
This study presents an FAP‐targeted LNP system designed to selectively target CAFs in CRPC. By inhibiting hexokinase 2 (HK2) and mitochondrial cytochrome c oxidase I (MTCO1), CAFs are reprogrammed from tumor‐promoting cells to immune‐supportive allies. This dual inhibition enhances T cell infiltration, suppresses angiogenesis, and improves the efficacy
Feng Qi, Dong Fu, Hongzhou Cai, Yuxiao Zheng, Ning Wang, Zicheng Xu   +5 more
wiley   +1 more source

Comprehensive Explorations of CCL28 in Lung Adenocarcinoma Immunotherapy and Experimental Validation

Journal of Inflammation Research, 2023
Xiangyu Su,1,2 Guoqing Wang,3 Shiya Zheng,2 Chang Ge,4 Fei Kong,4 Cailian Wang1,2 1School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University,
Su X, Wang G, Zheng S, Ge C, Kong F, Wang C   +5 more
doaj  

Blockade of IL-27 signaling ameliorates herpes stromal keratitis with upregulated CD4+ Foxp3+ regulatory T cells influx in mice

Indian Journal of Ophthalmology, 2019
Purpose: The purpose of this study was to investigate the production of IL-27 p28 and EBI3 in the ocular inflammatory sites, and the role of IL-27 signaling in a model of HSV-1 induced herpetic stromal keratitis (HSK).
Likun Xia, Tianchang Tan, Yang Li, Qiuyue Zhong, Mei Shi   +4 more
doaj   +1 more source