Results 91 to 100 of about 157,767 (395)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
In the present study, three series of novel celastrol derivatives were designed and synthesised by modifying the carboxylic acid at the 20th position with amino acid, amine, and triazole derivatives.
Hong-Jian Zhang, Guo-Rui Zhang, Hu-Ri Piao, Zhe-Shan Quan   +3 more
doaj   +1 more source

Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity

Molecules, 2017
Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization of dihydroartemisinin with triazole heterocycles has been proven to lead to enhanced therapeutic potential.
Sampad Jana, Shabina Iram, Joice Thomas, Muhammad Qasim Hayat, Christophe Pannecouque, Wim Dehaen   +5 more
doaj   +1 more source

Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner

mSphere, 2020
The number of invasive infections caused by Candida species is increasing worldwide. The incidence of candidiasis cases caused by non-albicans Candida species, such as Candida parapsilosis, is also increasing, and non-albicans Candida species are ...
Csaba Papp, Flóra Bohner, Katica Kocsis, Mónika Varga, András Szekeres, László Bodai, Jesse R. Willis, Toni Gabaldón, Renáta Tóth, Joshua D. Nosanchuk, Csaba Vágvölgyi, Attila Gácser   +11 more
doaj   +1 more source

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]

, 2010
The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr, Bock, David J. Stephens, Derby, Doherty, Erickson, Falnes, Feng, Feng, Fiebiger, Frédéric Boal, Fuchs, Gewald, Girod, Guetzoyan, Guy J. Clarkson, Helms, Herold, Hey, Hill, J. Michael Lord, Jackson, Johannes, Johannes, Johannes, Klausner, Lieu, Linstedt, Lu, Lucie J. Guetzoyan, Lynne M. Roberts, Macia, McKenzie, Monier, Nambiar, Nieland, Pavelka, Pelish, Perez-Victoria, Peyroche, Pirali, Plourde, Ponnambalam, Renault, Robert A. Spooner, Rostovtsev, Saenz, Saenz, Sandvig, Shima, Shin, Shin, Spooner, Spooner, Stechmann, Tai, Tsai, Viaud, Volpicelli-Daley, Wells, White, Wilcke, Yarrow, Yoshino, Zeghouf, Zhang, Zhao, Zolov   +67 more
core   +1 more source

Harnessing Synergistic Cooperation of Neighboring Active Motifs in Heterogeneous Catalysts for Enhanced Catalytic Performance

Advanced Materials, EarlyView.
This review examines the critical role of neighboring active motifs in heterogeneous catalysts, emphasizing how their synergistic cooperativity can be rationally designed to modulate catalytic properties. The discussion centers on the modulation of electronic and geometric structures, categorizing the catalytic systems into metal‐acid (Brønsted/Lewis ...
Peng Yuan, Ching Kit Tommy Wun, Tsz Woon Benedict Lo   +2 more
wiley   +1 more source

Near‐Zero Thermal Expansion in Coordination Polymer Cd(1,2,4‐Triazole)2(H2PO4)2

Angewandte Chemie, EarlyView.
The structural dynamics and the chemical bonding origin of a volumetric near‐zero thermal expansion in a coordination polymer across 25 K to 400 K is studied using multi‐temperature X‐ray crystallography and X‐ray electron density analysis. The lattice expansion in the a and c directions is counteracted by contraction along b axis, caused by concerted ...
Sounak Sarkar, Bo Brummerstedt Iversen
wiley   +2 more sources

Ethyl 2-(5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7-yl)pent-4-enoate

IUCrData, 2018
In the title molecule, C13H16N4O2, the fused triazolopyrimidine ring system is planar. In the crystal, inversion-related C—H...O hydrogen bonds form dimers that are linked into chains extending along the a-axis direction by inversion-related C—H...π(ring)
Sanae Lahmidi, Mohamed El Hafi, Ahmed Moussaif, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Di- and Tri-nuclear VIII and CrIII Complexes of Dipyridyltriazoles: Ligand Rearrangements, Mixed Valency and Ferromagnetic Coupling

Frontiers in Chemistry, 2020
The first dinuclear and trinuclear chromium(III) and dinuclear vanadium(III) complexes of N4-R-substituted-3,5-di(2-pyridyl)-1,2,4-triazole (Rdpt) ligands have been prepared by solvothermal complexations under inert atmospheres, and characterized.
Julia Rinck, Julia Rinck, Jonathan A. Kitchen, Jonathan A. Kitchen, Anthony B. Carter, Yanhua Lan, Christopher E. Anson, Karin Fink, Sally Brooker, Annie K. Powell, Annie K. Powell   +10 more
doaj   +1 more source

Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking [PDF]

, 2010
The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a–j) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a–j) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a–j) with sodium carbonate is presented.
Ahmed, Bhaskar, Brown, Chen, Curini, Dai, El Ashry, Feng, Gundla, Guy J. Clarkson, Han, Hassan, J. Michael Lord, Jennings, Joe, Khattab, Krueger, Kumar, Kumar, Lin, Lucie J. Guetzoyan, Lynne M. Roberts, Modena, Nagamatsu, Nagaraju, Phoujdar, Prakash, Prakash, Prakash, Prasad, Ram, Rashad, Rashad, Robert A. Spooner, Sadana, Shaban, Shaban, Sheldrick, Sheldrick, Shibahara, Shishoo, Spooner, Thakur, Tonnar, Vorob'ev, Wang, Yarrow   +46 more
core   +1 more source

Thermally Activated Delayed Fluorescence and Beyond. Photophysics and Material Design Strategies.

Advanced Photonics Research, EarlyView.
Photophysical properties of TADF molecules are determined by characteristic parameters that are discussed in detail(. Moreover, using femtosecond time‐resolved spectroscopy, quantum mechanical considerations, and state‐of‐art calculations, deeper understanding allows us to design breakthrough Cu(I) and organic TADF‐ OLED materials. For the latter ones,
Hartmut Yersin, Uwe Monkowius
wiley   +1 more source