Results 91 to 100 of about 46,961 (245)
ChemistryOpen, EarlyView.A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda +7 more
wiley +1 more source
ChemistryOpen, EarlyView.New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha +6 more
wiley +1 more source
Diverse reactivity of maleimides in polymer science and beyond
Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick +2 more
wiley +1 more source
Pest Management Science, EarlyView.Penetration of a pesticide mimic into a spring onion leaf due to the presence of a surfactant additive. Abstract BACKGROUND Effective pesticide action is crucial for optimizing efficacy and minimizing environmental impact, particularly with the increasing reliance on systemic pesticides.
Begüm Demirkurt +2 more
wiley +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Rapid Communications in Mass Spectrometry, EarlyView.ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino +3 more
wiley +1 more source
BiomedicinesNucleopeptides (NPs) represent synthetic polymers created by attaching nucleobases to the side chains of amino acid residues within peptides. These compounds amalgamate the characteristics of peptides and nucleic acids, showcasing a unique ability to ...
Piotr Mucha +6 more
doaj +1 more source
Engineering Proton Conductive Metal–Organic Glasses Through Secondary Network Formers
Small, EarlyView.Incorporating secondary network formers enables access to metal–organic glass with tunable structures and properties. This strategy allows systematic control over key metrics, including anhydrous proton conductivities up to 2.6 mS cm−1 at 150°C, a linear increase in glass transition temperature from 11.0°C to 57.4°C, and more than a 200‐fold increase ...
Nattapol Ma +3 more
wiley +1 more source
Beyond Initial Activity: A Perspective Toward Durable Cu‐Based Catalysts for CO2 Electroreduction
SusMat, EarlyView.This perspective summarizes multi‑scale strategies to enhance the stability of Cu‑based catalysts for CO2 electroreduction, spanning atomic‑scale design, organic molecular and polymeric modifications, active sites regeneration, and electrolysis system engineering.
Lijuan Yang +3 more
wiley +1 more source