Results 101 to 110 of about 81,000 (236)

Directional Macrocycle Transport, Release, and Recapture Enabled by a Rotaxane Transporter

Chemistry – A European Journal, EarlyView.
This study represents a bistable rotaxane that enables the directional shuttling, release, and recapture of a dibenzo‐24‐crown‐8 macrocycle upon addition of suitable chemical stimuli. This two‐step molecular transport and release can be followed by NMR and distinct changes in the molecular fluorescence. Based on rational molecular design, the liberated
Sohom Kundu, Shubhadip Mallick, Jan Riebe, Jochen Niemeyer   +3 more
wiley   +1 more source

Core‐Twisted, Cationic Perylene Diimides; Homochiral Dimerization and Chiroptical Anion Sensing

Chemistry – A European Journal, EarlyView.
The installation of two 3‐methyl‐1,2,3‐triazolium heterocycles on the aromatic core of a perylene diimide (PDI) generates a twisted and cationic organic dye. As potent hydrogen bond donors, these groups enable the PDI to self‐assemble into discrete and robust homochiral dimers in solution.
Denis Hartmann, Jamie S. Hillis, Lucy E. Walker, Timothy A. Barendt   +3 more
wiley   +1 more source

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

Chemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker, Jan‐Simon Behnke, Leonhard H. Urner   +2 more
wiley   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases. [PDF]

Trop Med Infect Dis
Isern JA, Carlucci R, Labadie GR, Porta EOJ.   +3 more
europepmc   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, EarlyView.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

Doubling of triazole resistance rates in invasive aspergillosis over a 10-year period, Belgium, 1 April 2022 to 31 March 2023. [PDF]

Euro Surveill
Cuypers L, Aerts R, Van de Gaer O, Vinken L, Merckx R, Gerils V, Vande Velde G, Reséndiz-Sharpe A, Maertens J, Lagrou K.   +9 more
europepmc   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

1,3-Dipolar Cycloaddition and Mannich Reactions of Alkynyl Triterpenes: New Trends in Synthetic Strategies and Pharmacological Applications. [PDF]

Int J Mol Sci
Petrova AV, Kazakova OB.
europepmc   +1 more source

35Cl NMR of Metal‐Organic Frameworks: What Can We Learn?

Chemistry–Methods, EarlyView.
35Cl solid‐state NMR of MOFs offers insights into bonding mode and character, hydrogen bonding, phase transitions, and reaction products, even near paramagnetic centers. 35Cl NMR parameters reflect Cl coordination and local geometry. DFT methods accurately predict 35Cl NMR parameters. This 35Cl NMR/DFT approach is applicable to other MOFs and materials.
Wanli Zhang, Bryan E. G. Lucier, Mathew J. Willans, Yining Huang   +3 more
wiley   +1 more source