Results 101 to 110 of about 46,961 (245)
Yeast, EarlyView.Candidozyma cisalpinoae sp. nov. represents a distinct species within the Candidozyma clade, supported by multilocus phylogeny, genome‐scale metrics, and phenotypic traits. Although isolated from floral substrates, this species displays several traits commonly associated with opportunistic pathogenic yeasts.
Anna Paula O. Tironi +12 more
wiley +1 more source
Acta Crystallographica Section C, EarlyView.X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme +5 more
wiley +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta +5 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT The development of dual‐target inhibitors represents a cost‐effective strategy for integrated pest management. Here, we report the first dual‐target inhibitors designed against the evolutionarily conserved domain of phytoene synthase (PSY), a key enzyme in carotenoid biosynthesis.
Di Zhang +11 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT As global warming continues, rising temperatures significantly alter the interactions between wheat and the stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst). Utilising high‐temperature all‐stage (HTAS) resistance to Pst is a novel strategy for breeding climate and disease resilient wheat cultivars.
Yifeng Shi +6 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT The ripening of climacteric fruits is characterised by a sharp increase in ethylene production, coinciding with the conversion of starch into soluble sugars. However, the regulatory interplay between ethylene and starch degradation in apple remains largely unclear. Here, we report a negative correlation between starch accumulation and ethylene
Fan Xiao +8 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Heat stress significantly damages crop yield and quality. PLATZ (PLANT A/T‐RICH SEQUENCE‐AND ZINC‐BINDING PROTEIN) transcription factors play pivotal roles in plant growth, development, and environmental stress responses. While the functions of PLATZ members in response to drought and salt stress are well characterised, their roles in heat ...
Xue Gong +7 more
wiley +1 more source