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Haematotoxicity of trichothecenes
Toxicology Letters, 2004Human toxicosis induced by consumption of foodstuffs contaminated with trichothecenes presents one common major symptom: a haematological perturbation manifesting principally as thrombocytopenia and leukopenia. The patients have rapidly progressing coagulation problems, and compromised resistance to infections.
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Metabolic pathways of trichothecenes
Drug Metabolism Reviews, 2009Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-
Qinghua, Wu +4 more
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Prevention strategies for trichothecenes
Toxicology Letters, 2004Contamination of cereal commodities with mycotoxins represents a significant hazard to consumer health and has thus received increasing attention from food safety authorities and legislators. For trichothecenes, and deoxynivalenol (DON) in particular, the imminent implementation of legislative limits has focused attention on ways to prevent entry of ...
David, Aldred, Naresh, Magan
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ROS: Trichothecenesâ handy weapon?
Food and Chemical Toxicology, 2020Trichothecenes are a class of toxic secondary metabolites produced by filamentous fungi such as Fusarium, which pose a threat to human and animal health. Among them, T-2 toxin and deoxynivalenol (DON) have attracted the most attention because of their extensive pollution and strong toxicity.
Zhanyong Wei +2 more
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Chemical Synthesis of the Trichothecenes
1985That research in the trichothecene field is an area of intense interest cannot be disputed. In the years 1982 and 1983, there were more than 500 publications dealing with this subject, including more than 30 reviews. In addition, a comprehensive monograph has recently appeared (151).
P G, McDougal, N R, Schmuff
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A yeast bioassay for trichothecenes
Natural Toxins, 1999Like all eucaryotic cells, yeasts are sensitive to trichothecenes, especially T-2 toxin and verrucarin A. Based on this sensitivity, a yeast bioassay was developed to evaluate the toxicity of corn samples. The bioassay was optimized using spiked maize extracts. The toxicity of samples was defined as toxicity equivalent to a certain concentration of T-2
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Targeting Trichothecene Biosynthetic Genes
2016Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong +4 more
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Trichothecenes and their analysis
Journal of the American Oil Chemists' Society, 1979AbstractThe analysis of foods and feeds for the naturally occurringFusarium produced trichothecenes is reviewed. Each major step (extraction, purification and detectionâquantitation) is discussed. Although none of the extraction solvents has been thoroughly evaluated, aqueous metanol is the preferred system in most of the published procedures.
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Influence of processing on trichothecene levels
Toxicology Letters, 2004Trichothecene mycotoxins frequently occur in cereal grains that are intended for food production. The process of converting grains into food and drinks for consumers has significant effects on the levels of toxins in the final food. Surveillance of retail food and drinks of cereal origin demonstrates that trichothecenes do survive the production ...
Clare M, Hazel, Sue, Patel
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