Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX) [PDF]
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
doaj +4 more sources
Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. [PDF]
Basic & Clinical Pharmacology & Toxicology, 2005 Abstract: The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy‐substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half‐times were calculated.
B. Antonijević +6 more
semanticscholar +18 more sources
Understand the interaction modes and reactivity of trimedoxime toward MmAChE inhibited by nerve agents: theoretical and experimental Aspects [PDF]
International Journal of Molecular Sciences, 2020 The organophosphorus compounds (OP) are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order
A. A. Castro +6 more
semanticscholar +4 more sources
A COMPARISON OF THE NEUROPROTECTIVE EFFICACY OF INDIVIDUAL OXIMES (HI-6, TRIMEDOXIME, K203) AND THEIR MIXTURES (HI-6 + TRIMEDOXIME, HI-6 + K203) IN CYCLOSARIN-POISONED RATS [PDF]
Military Medical Science Letters, 2011 The ability of three oximes (HI-6, trimedoxime, K203) to reduce cyclosarin-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of two combinations of oximes (HI-6 + trimedoxime, HI-6 + K203) using a functional ...
J. Kassa, J. Karasova
semanticscholar +2 more sources
A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun. [PDF]
Biomedical Papers, 2005 Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to highly toxic organophosphorus compounds misused as chemical warfare agents for military as well as terroristic purposes.
J. Kassa, K. Kuča, J. Cabal
semanticscholar +3 more sources
The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime. [PDF]
Front Neurosci, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Lorke DE, Petroianu GA.
europepmc +3 more sources
A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management. [PDF]
Front Toxicol, 2022 Background: The whole world has learned about the existence of a highly toxic neuro-paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used during the wars of decades ago, which also had harmful and irreversible effects ...
Charejoo A +3 more
europepmc +3 more sources
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats. [PDF]
Int J Mol Sci, 2009 Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats.
Karasova JZ +5 more
europepmc +6 more sources
Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats. [PDF]
Int J Mol Sci, 2008 The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun.
Karasova JZ +5 more
europepmc +4 more sources
Pediatric poisoning from trimedoxime (TMB4) and atropine automatic injectors.
The Journal of Pediatrics, 2005 To describe the effects of combined trimedoxime (TMB4) and atropine poisoning from automatic injectors (AI) in children.Data was collected from two sources: calls to the Israel Poison Information Center (IPIC) during a 1-year period and a cohort of children who presented to pediatric emergency departments (EDs) after unintentional injection of an AI ...
E. Kozer +5 more
semanticscholar +3 more sources