Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. [PDF]
Int J Mol Sci, 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a ...
Jun D +5 more
europepmc +4 more sources
The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents. [PDF]
Interdiscip Toxicol, 2008 Kassa J +4 more
europepmc +3 more sources
Stability of trimedoxime in concentrated acidic injectable solutions. [PDF]
Military Medicine, 1999 The degradation of trimedoxime in concentrated (114 mg/ml) acidic solutions was studied at several temperatures in the pH range 3.0 to 4.3. The degradation profile showed a relationship indicative of first-order kinetics. Trimedoxime was found to be stable in the pH range 3.0 to 3.8, with maximum stability at pH 3.0.
S. Rubnov +4 more
semanticscholar +3 more sources
Therapeutic efficacy of a novel bispyridinium oxime K203 and commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) in soman-poisoned male rats and mice [PDF]
Journal of Applied Biomedicine, 2013 The potency of a novel oxime K203 in reactivating soman-inhibited acetylcholinesterase and reducing acute toxicity of soman was compared with commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) using in vivo methods. The study determining percentage of reactivation of soman-inhibited blood and tissue acetylcholinesterase in rats showed that ...
J. Kassa +2 more
semanticscholar +2 more sources
The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder [PDF]
Journal of Applied Biomedicine, 2010 Summary Trimedoxime is a bisquaternary oxime that is widely used in the treatment of organophosphorous poisoning caused by tabun and paraoxon. We tested its affinity to acetylcholinesterase (AChE), its mechanism of interaction and effect on the cholinergic system of the rat bladder.
O. Soukup +7 more
semanticscholar +2 more sources
Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes
Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021 For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some ...
Rauda A. Mohamed +8 more
wiley +1 more source
Comparison of the neuroprotective effects of the newly developed oximes (K027, K048) with trimedoxime in tabun-poisoned rats [PDF]
Journal of Applied Biomedicine, 2006 J. Kassa, G. Kunešová
semanticscholar +2 more sources
Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun‐Induced Neurotoxicity in Rats [PDF]
Basic & Clinical Pharmacology & Toxicology, 2013 AbstractThe ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun‐induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (200 μg/
J. Kassa, J. Misík, J. Karasova
semanticscholar +3 more sources
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2010 The potency of newly developed bispyridinium compound K203 and its fluorinated analog KR-22836 in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
J. Kassa +5 more
semanticscholar +3 more sources
An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]
, 2014 Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina +3 more
core +4 more sources