Results 31 to 40 of about 18,891 (189)
Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
Frontiers in Cardiovascular Medicine, 2021 Atherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern.
BingYu Wang +6 more
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Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
Microbiome, 2018 Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles +12 more
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The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]
PLoS ONE, 2016 UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen +8 more
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Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production
Gut MicrobesTrimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease.
Efrain Ricardo Torres +2 more
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Diabetes, Metabolic Syndrome and Obesity, 2023 Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
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Pressing the trimethylamine N-oxide narrative
AME Medical Journal, 2017 We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
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Association of diet with circulating trimethylamine-N-oxide concentration [PDF]
The American Journal of Clinical Nutrition, 2020 Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult
Rikuta Hamaya +7 more
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Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients [PDF]
Journal of the American Society of Nephrology, 2016 Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of death is higher in white than in black patients. The underlying mechanisms for these findings are unknown. We determined the association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcomes in hemodialysis patients and ...
Tariq, Shafi +8 more
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Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide [PDF]
APMIS, 2020 The increasing prevalence of cardiovascular diseases cannot adequately be explained by traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota‐derived numerous metabolites are contributors to atherosclerotic events.
Zhu, Yingqian, Li, Qingqing, Jiang, Hua
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Research advances of trimethylamine N-oxide and chronic kidney diseases
Linchuang shenzangbing zazhi, 2021 Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun +3 more
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