Results 51 to 60 of about 18,891 (189)

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

A Multi-omic Association Study of Trimethylamine N-Oxide [PDF]

Cell Reports, 2018
Trimethylamine N-oxide (TMAO) is a circulating metabolite that has been implicated in the development of atherosclerosis and cardiovascular disease (CVD). In this paper, we identify blood markers, metabolites, proteins, gut microbiota patterns, and diets that are significantly associated with levels of plasma TMAO.
Ohad, Manor, Niha, Zubair, Matthew P, Conomos, Xiaojing, Xu, Jesse E, Rohwer, Cynthia E, Krafft, Jennifer C, Lovejoy, Andrew T, Magis   +7 more
openaire   +2 more sources

Trimethylamine N‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProduction of the proatherogenic metabolite, trimethylamine N‐oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease in ...
Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W. H. Wilson Tang   +5 more
doaj   +1 more source

Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study

Nutrition & Metabolism, 2020
Background Accumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians.
Yuxiang Dai, Qianqian Tian, Jing Si, Zhonghan Sun, Shalaimaiti Shali, Lili Xu, Daoyuan Ren, Shufu Chang, Xin Dong, Hongxia Zhao, Zhendong Mei, Yan Zheng, Junbo Ge   +12 more
doaj   +1 more source

The food-derived metabolite trimethylamine and trimethylamine-N-oxide promote colorectal cancer progression via SREBF1

Ecotoxicology and Environmental Safety
Colorectal cancer (CRC) is characterised by microbial dysbiosis. Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) are gut microbiota-derived metabolites produced from dietary precursors that are implicated in CRC progression.
Yang Yan, Jiaxuan Li, Hejia Xu, Chen Yang, Guifang Li, Yanyan Feng, Qian Wang, Li Li, Rendi Wu, Hairong Sun, Ting Zhang, Fang Wang, Yong Mao   +12 more
doaj   +1 more source

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide. [PDF]

PLoS ONE, 2017
Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones.
Aaron L Miller, W Austin Elam, Betty H Johnson, Shagufta H Khan, Raj Kumar, E Brad Thompson   +5 more
doaj   +1 more source

Trimethylamine-N-Oxide

JACC: Basic to Translational Science, 2021
Fadi W. Adel, Horng H. Chen
openaire   +1 more source

Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke

Biomolecules
Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite, the production of which in vivo is mainly regulated by dietary choices, gut microbiota, and the hepatic enzyme flavin monooxygenase (FMO), while its elimination occurs via the kidneys.
Zhen Li, Xinyi He, Qi Fang, Xulong Yin
doaj   +1 more source

The effect of trimethylamine N-oxide on the metabolism of visceral white adipose tissue in spontaneously hypertensive rat

, 2022
Guodong He, Xiaocong Liu, Xing-Hua Hou, Yingqing Feng   +3 more
openalex   +2 more sources

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Frontiers in Physiology, 2019
Background/Aims: Gut microbiota has been reported to correlate with a higher mortality and worse prognosis of cardiovascular diseases. Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of specific dietary nutrients, which is linked ...
Xueling Li, Jin Geng, Jinxuan Zhao, Qianqian Ni, Chenze Zhao, Yaru Zheng, Xiaomin Chen, Lihong Wang   +7 more
doaj   +1 more source