Results 11 to 20 of about 10,078 (159)

Trimethylamine N-oxide (TMAO) in human health. [PDF]

EXCLI J, 2021
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and diseases, this topic is very popular and is often taken up by researchers. TMAO is a low molecular weight compound that belongs to the class of amine oxides. It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 ...
Gatarek P, Kaluzna-Czaplinska J.
europepmc   +3 more sources

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases. [PDF]

Biomedicines, 2023
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. There are factors that affect one’s TMAO level, such as diet, drugs, age, and hormones, among others.
Constantino-Jonapa LA, Espinoza-Palacios Y, Escalona-Montaño AR, Hernández-Ruiz P, Amezcua-Guerra LM, Amedei A, Aguirre-García MM.   +6 more
europepmc   +4 more sources

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations. [PDF]

Nutrients, 2021
Individual differences in the chronotype, an attitude that best expresses the individual circadian preference in behavioral and biological rhythms, have been associated with cardiometabolic risk and gut dysbiosis. Up to now, there are no studies evaluating the association between chronotypes and circulating TMAO concentrations, a predictor of ...
Barrea L, Muscogiuri G, Pugliese G, Graziadio C, Maisto M, Pivari F, Falco A, Tenore GC, Colao A, Savastano S.   +9 more
europepmc   +5 more sources

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia. [PDF]

Alzheimers Res Ther
AbstractBackgroundThe gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, and dementia remains uncertain.MethodsIn the population-based Rotterdam Study, we ...
Yaqub A, Vojinovic D, Vernooij MW, Slagboom PE, Ghanbari M, Beekman M, van der Grond J, Hankemeier T, van Duijn CM, Ikram MA, Ahmad S.   +10 more
europepmc   +6 more sources

Trimethylamine N-oxide (TMAO) in patients with subarachnoid hemorrhage: a prospective observational study. [PDF]

Acta Neurochir (Wien), 2023
Abstract Background It is suspected that microbiome-derived trimethylamine N-oxide (TMAO) may enhance platelet responsiveness and accordingly be thrombophilic. The purpose of this prospective observational study is to evaluate TMAO in patients with subarachnoid hemorrhage (SAH) and compare it with a control group.
Emonds JJ, Arlt F, Gaudl A, Reinicke M, Heinemann M, Lindner D, Laudi S, Ceglarek U, Meixensberger J.   +8 more
europepmc   +3 more sources

Association of Urinary and Plasma Levels of Trimethylamine N-Oxide (TMAO) with Foods. [PDF]

Nutrients, 2021
Introduction: Trimethylamine N-oxide (TMAO) may play a key mediator role in the relationship between the diet, gut microbiota and cardiovascular diseases, particularly in people with kidney failure. The aim of this review is to evaluate which foods have a greater influence on blood or urinary trimethylamine N-oxide (TMAO) levels.
Lombardo M, Aulisa G, Marcon D, Rizzo G, Tarsisano MG, Di Renzo L, Federici M, Caprio M, De Lorenzo A.   +8 more
europepmc   +6 more sources

Neighborhood Environment Associates with Trimethylamine-N-Oxide (TMAO) as a Cardiovascular Risk Marker. [PDF]

Int J Environ Res Public Health, 2021
Background: Neighborhoods and the microbiome are linked to cardiovascular disease (CVD), yet investigations to identify microbiome-related factors at neighborhood levels have not been widely investigated. We sought to explore relationships between neighborhood deprivation index (NDI) and the microbial metabolite, trimethylamine-N-oxide. We hypothesized
Farmer N, Gutierrez-Huerta CA, Turner BS, Mitchell VM, Collins BS, Baumer Y, Wallen GR, Powell-Wiley TM.   +7 more
europepmc   +4 more sources

Impact of trimethylamine N-oxide (TMAO) metaorganismal pathway on cardiovascular disease. [PDF]

J Lab Precis Med, 2020
Host-microbes interaction plays a crucial role in cardiovascular disease (CVD) pathogenesis, mechanistically via metaorganismal pathways. The trimethylamine N-oxide (TMAO) metaorganismal pathway is the most deeply investigated one, which comprises trimethylamine precursors, such as choline, trimethylamine lyase, trimethylamine, host liver FMO3, TMAO ...
Zhao Y, Wang Z.
europepmc   +3 more sources

Temporal Course of Plasma Trimethylamine N-Oxide (TMAO) Levels in ST-Elevation Myocardial Infarction. [PDF]

J Clin Med, 2021
The gut metabolite trimethylamine N-oxide (TMAO) at admission has a prognostic value in ST-elevation myocardial infarction (STEMI) patients. However, its sequential changes and relationship with long-term infarct-related outcomes after primary percutaneous coronary intervention (PCI) remain elusive.
Almesned MA, Prins FM, Lipšic E, Connelly MA, Garcia E, Dullaart RPF, Groot HE, van der Harst P.   +7 more
europepmc   +5 more sources

Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role? [PDF]

Nutrition Reviews, 2021
AbstractAlzheimer’s disease (AD) is a neurodegenerative disease that affects memory and cognitive function. Clinical evidence has put into question our current understanding of AD development, propelling researchers to look into further avenues. Gut microbiota has emerged as a potential player in AD pathophysiology. Lifestyle factors, such as diet, can
Pablo, Arrona Cardoza, Micheil B, Spillane, Elisa, Morales Marroquin   +2 more
openaire   +2 more sources