Results 21 to 30 of about 10,078 (159)
Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health. [PDF]
MetabolitesThe intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism that plays a crucial role in regulating health by producing biologically active molecules that can enter systemic circulation.
Caradonna E +11 more
europepmc +4 more sources
Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease [PDF]
Scientific Reports, 2019 AbstractPeripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden.
Carmen Roncal +12 more
openaire +3 more sources
npj Biofilms and Microbiomes, 2022 Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO), formed from metaorganismal metabolism of ʟ-carnitine.
Suraphan Panyod +20 more
doaj +1 more source
Trimethylamine N-Oxide (TMAO) and Indoxyl Sulfate Concentrations in Patients with Alcohol Use Disorder. [PDF]
Nutrients, 2022 Background: Trimethylamine N-oxide (TMAO) and indoxyl sulfate (IS) are produced by the microbiota and the liver, and can contribute to brain aging and impaired cognitive function. This study aims to examine serum TMAO and IS concentrations in patients with alcohol-use disorder (AUD) at the entry for alcohol withdrawal, and the relationships with ...
Coulbault L +5 more
europepmc +5 more sources
ESC Heart Failure, 2020 Aims The aim of this study was to investigate whether ethnicity influences the associations between trimethylamine N‐oxide (TMAO) levels and heart failure (HF) outcomes.
Yoshiyuki Yazaki +16 more
doaj +1 more source
Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
Frontiers in Cardiovascular Medicine, 2022 Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Lele Jing +6 more
doaj +1 more source
Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO) [PDF]
Proceedings of the National Academy of Sciences, 2014 SignificanceThe ability of trimethylamine N-oxide (TMAO) to counteract osmotic stress along with the deleterious effects of denaturants such as urea is fascinating and has inspired many studies. To further our understanding of how TMAO acts to stabilize folded proteins, we carry out an infrared experiment designed to probe the microscopic details of ...
Jianqiang, Ma +2 more
openaire +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine.
Chelsea L. Organ +8 more
doaj +1 more source
JCI Insight, 2023 We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI).
Fatma Saaoud +18 more
doaj +1 more source
Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism [PDF]
Lipids in Health and Disease, 2018 Recently, trimethylamine-N-oxide (TMAO) plasma levels have been proved to be associated with atherosclerosis development. Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess cholesterol in body is an effective way.
Lin Ding +7 more
openaire +3 more sources