Results 1 to 10 of about 4,709 (168)
Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
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Insights into the protein domains of C-VI TRIM subfamily in viral infection [PDF]
Frontiers in Cellular and Infection MicrobiologyTripartite motif (TRIM) proteins, defined by their conserved RBCC domain architecture, play key roles in various cellular processes and virus-host interactions.
Bbumba Patrick +5 more
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A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases [PDF]
VirusesTripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity.
Adam Hage, Mikhaila Janes, Sonja M. Best
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Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis [PDF]
Translational OncologyGliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases.
Wenjie Wu +3 more
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TRIM proteins: A 'swiss army knife' of antiviral immunity. [PDF]
PLoS PathogensWith their modular structure and E3 ubiquitin ligase activity, Tripartite motif (TRIM) proteins interact with a wide range of cellular and viral substrates. This review summarizes how they have emerged as key players in the antiviral response.
Elise Chabot +2 more
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Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design [PDF]
Journal of Structural Biology: XTripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi +4 more
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The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion [PDF]
VirusesTripartite motif (TRIM) 25 is a member of the TRIM E3 ubiquitin ligase family, which plays multiple roles in anti-tumor and antiviral defenses through various pathways.
Qianxun Liu +3 more
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Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease
Cells, 2022 The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest during the last two decades [...]
Germana Meroni, Solange Desagher
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Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
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The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
Frontiers in Oncology, 2023 Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression.
Yiqing Yang +24 more
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