Results 11 to 20 of about 4,709 (168)

The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury [PDF]

Journal of Immunology Research, 2021
Acute lung injury (ALI) is an inflammatory disorder of the lung that causes high mortality and lacks any pharmacological intervention. Ubiquitination plays a critical role in the pathogenesis of ALI as it regulates the alveolocapillary barrier and the ...
Yingjie Huang, Yue Xiao, Xuekang Zhang, Xuan Huang, Yong Li   +4 more
doaj   +4 more sources

Bioinformatics analysis of immune infiltrates and tripartite motif (TRIM) family genes in hepatocellular carcinoma. [PDF]

J Gastrointest Oncol, 2022
The tripartite motif (TRIM) family are important members of the Gene-finger-containing E3 ubiquitin-conjugating enzyme and are involved in the progression of hepatocellular carcinoma (HCC). Previous studies have largely focused on gene expression and molecular pathways, while the underlying role of the TRIM family in the tumor immune microenvironment ...
Cao J, Su B, Peng R, Tang H, Tu D, Tang Y, Zhou J, Jiang G, Jin S, Wang Q, Wang A, Liu R, Deng Q, Zhang C, Bai D.   +14 more
europepmc   +3 more sources

Prognostic value of tripartite motif (TRIM) family gene signature from bronchoalveolar lavage cells in idiopathic pulmonary fibrosis. [PDF]

BMC Pulm Med, 2022
Abstract Background Tripartite motif (TRIM) family genes get involved in the pathogenesis and development of various biological processes; however, the prognostic value of TRIM genes for idiopathic pulmonary fibrosis (IPF) needs to be explored.
Zhou M, Ouyang J, Zhang G, Zhu X.
europepmc   +4 more sources

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. [PDF]

EMBO Mol Med, 2011
The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines ...
Kawai T, Akira S.
europepmc   +3 more sources

Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. [PDF]

J Biol Chem, 2011
Many tripartite motif (TRIM) proteins self-associate, forming dimers and higher order complexes. For example, dimers of TRIM5α, a host factor that restricts retrovirus infection, assemble into higher order arrays on the surface of the viral capsid, resulting in an increase in avidity.
Li X, Yeung DF, Fiegen AM, Sodroski J.
europepmc   +4 more sources

Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins [PDF]

Frontiers in Cell and Developmental Biology, 2020
Protein quality control (PQC) is pivotal for eukaryotic cells to eliminate misfolded proteins and maintain cellular homeostasis. A decreased or increased capacity of PQC is associated with various diseases, e.g., neurodegenerative diseases and cancers. Recently, increasing evidences have suggested that tripartite motif-containing family proteins (TRIMs)
Litian Zhang, Litian Zhang, Lukman O. Afolabi, Lukman O. Afolabi, Xiaochun Wan, Xiaochun Wan, Yang Li, Liang Chen   +7 more
openaire   +3 more sources

TRIM proteins in hepatocellular carcinoma

Journal of Biomedical Science, 2022
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-yang Ding, Bixiang Zhang   +5 more
doaj   +1 more source

TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases

Cells, 2021
Tripartite motif (TRIM) proteins are RING E3 ubiquitin ligases defined by a shared domain structure. Several of them are implicated in rare genetic diseases, and mutations in TRIM32 and TRIM-like malin are associated with Limb-Girdle Muscular Dystrophy ...
Lorena Kumarasinghe, Lu Xiong, Maria Adelaida Garcia-Gimeno, Elisa Lazzari, Pascual Sanz, Germana Meroni   +5 more
doaj   +1 more source

An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer. [PDF]

Hum Genomics
AbstractMost TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a comprehensive investigation for the entire family in gastric cancer (GC). By combining the TCGA and GEO databases, common TRIM family members (TRIMs) were obtained to investigate gene expression, gene
Ding Y, Lu Y, Guo J, Chen S, Han X, Wang S, Zhang M, Wang R, Song J, Wang K, Qiu W, Qi W.   +11 more
europepmc   +4 more sources

Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function [PDF]

Proceedings of the National Academy of Sciences, 2007
The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5α and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions.
Leo C, James, Anthony H, Keeble, Zahra, Khan, David A, Rhodes, John, Trowsdale   +4 more
openaire   +2 more sources