Frontiers in Oncology, 2021 Emerging evidence suggests that the tripartite motif (TRIM) family play important roles in tumor development and progression. Tripartite motif-containing 50 (TRIM50) is a member of the TRIM family, but little is known regarding its expression and ...
Rongkun Li +5 more
doaj +1 more source
trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
eLife, 2022 The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Whether appropriate levels of CED-1 are maintained for executing the engulfment function remains unknown ...
Lei Yuan +4 more
doaj +1 more source
Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases
Carcinogenesis, 2021 Abstract Tripartite motif (TRIM) family proteins are post-translational protein modifiers with E3-ubiquitin ligase activity, thereby involved in various biological processes. The molecular mechanisms driving prostate cancer (PCa) bone metastasis (BM) are incompletely understood, and targetable genetic alterations are lacking in the ...
Anne Offermann +20 more
openaire +3 more sources
Silencing of tripartite motif (TRIM) 29 inhibits proliferation and invasion and increases chemosensitivity to cisplatin in human lung squamous cancer NCI-H520 cells. [PDF]
Thorac Cancer, 2015 AbstractBackgroundTRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported to be a tumor suppressor or have oncogenic function in many cancer types. The aim of this study was to investigate whether downregulation of TRIM29 by small interfering ribonucleic acid (siRNA) could inhibit cell proliferation and invasion and increase ...
Liu C, Huang X, Hou S, Hu B, Li H.
europepmc +4 more sources
Genome-Wide Identification and Expression Analysis of Potential Antiviral Tripartite Motif Proteins (TRIMs) in Grass Carp (Ctenopharyngodon idella) [PDF]
Biology, 2021 Tripartite motif proteins (TRIMs), especially B30.2 domain-containing TRIMs (TRIMs-B30.2), are increasingly well known for their antiviral immune functions in mammals, while antiviral TRIMs are far from being identified in teleosts. In the present study, we identified a total of 42 CiTRIMs from the genome of grass carp, Ctenopharyngodon idella, an ...
Beibei Qin +5 more
openaire +3 more sources
Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
doaj +1 more source
The role of TRIM family in metabolic associated fatty liver disease
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
doaj +1 more source
Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages. [PDF]
VirusesBackground: The Tripartite motif (TRIM) family includes more than 80 distinct human genes. Their function has been implicated in regulating important cellular processes, including intracellular signaling, transcription, autophagy, and innate immunity.
Hernández-Sarmiento LJ +3 more
europepmc +4 more sources
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Nature Communications, 2020 Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid ...
Alvin Yu +5 more
doaj +1 more source
TRIM family contribute to tumorigenesis, cancer development, and drug resistance
Experimental Hematology & Oncology, 2022 The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes.
Ning Huang +6 more
doaj +1 more source