The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6. [PDF]
J Immunol, 2015 Abstract Tripartite motif (TRIM) protein TRIM5 of the primate species restricts replication of HIV and other retroviruses. Whereas primates have a single TRIM5 gene, the corresponding locus in the mouse has expanded during evolution, now containing more than eight related genes.
Chang TH, Yoshimi R, Ozato K.
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Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection [PDF]
Proceedings of the National Academy of Sciences, 2006 Primate tripartite motif 5α (TRIM5α) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIM5 is located in a paralogous cluster that includes TRIM6 , TRIM34 , and TRIM22 . Although TRIM6 and
Si, Zhihai +11 more
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TRIM 24 (tripartite motif-containing 24) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TRIM 24 (tripartite motif-containing 24), with data on DNA, on the protein encoded, and where the gene is implicated.
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BMC Evolutionary Biology, 2008 Background The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that can be associated with a C-terminal domain.
Fontanella Bianca +4 more
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TRIM Proteins and Their Roles in the Influenza Virus Life Cycle
Microorganisms, 2020 The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects ...
Hye-Ra Lee +3 more
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To TRIM the Immunity: From Innate to Adaptive Immunity
Frontiers in Immunology, 2020 The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang +3 more
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Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]
PLoS ONE, 2013 Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang +3 more
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Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers
Cells, 2022 Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
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Comparative structural analyses of the NHL domains from the human E3 ligase TRIM–NHL family
IUCrJ, 2022 Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of the RING-type E3 ubiquitin ligases that play a role in diverse processes from homeostasis and immune response to viral restriction.
Apirat Chaikuad +3 more
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