Results 1 to 10 of about 34,874 (291)
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential [PDF]
Nature Communications, 2020 TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ...
Hanzhi Zhang +11 more
doaj +4 more sources
GM1 promotes TrkA-mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA [PDF]
Journal of Neurochemistry, 2019 Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA\u2013GM1 oligosaccharide complex at the cell surface.
D.Y. Pomè +9 more
core +6 more sources
Stem Cell Research & Therapy, 2021 Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action remains unclear.
Yang Wang +5 more
doaj +2 more sources
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Biomolecules, 2020 The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin +7 more
doaj +2 more sources
Optical activation of TrkA signaling [PDF]
ACS Synthetic Biology, 2018 Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer’s disease, chronic pain ...
Liting Duan +7 more
semanticscholar +7 more sources
Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez +20 more
doaj +3 more sources
Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
eLife, 2018 The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye +2 more
doaj +2 more sources
NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]
PLoS ONE, 2012 Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor +3 more
doaj +6 more sources
TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts
Neural Regeneration Research, 2019 We previously demonstrated that overexpression of tropomyosin receptor kinase A (TrkA) promotes the survival and Schwann cell-like differentiation of bone marrow stromal stem cells in nerve grafts, thereby enhancing the regeneration and functional ...
Mei-Ge Zheng +10 more
doaj +2 more sources
FASEB BioAdvances, 2020 Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner +7 more
doaj +2 more sources