Results 1 to 10 of about 35,994 (298)

Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats

Stem Cell Research & Therapy, 2021
Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action remains unclear.
Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang, Limin Rong   +5 more
doaj   +2 more sources

The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer

Biomolecules, 2020
The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M. Walker, Hubert Hondermarck, Sam Faulkner   +7 more
doaj   +2 more sources

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

eLife, 2018
The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye, Kathryn M Lehigh, David D Ginty   +2 more
doaj   +2 more sources

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma. [PDF]

J Cutan Pathol
ABSTRACT Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen‐activated protein kinase (MAPK) and extracellular signal‐regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood.
Nagarkar A, Turbeville J, Hinshaw MA, LeBoit PE, Gagan J, Raffeld M, Aldape K, Shah N, Barr FG, Xi L, Lee I, Ferrone CK, Pack SD, Kaplan R, Malone MFW, Yohe M, Sargen MR.   +16 more
europepmc   +2 more sources

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

Nature Communications, 2020
TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ...
Hanzhi Zhang, Yaping Pan, Liya Hu, M. Ashley Hudson, Katrina S. Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, B. V. Venkataram Prasad, Steve W. Lockless, Wah Chiu, Ming Zhou   +11 more
doaj   +2 more sources

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts

Neural Regeneration Research, 2019
We previously demonstrated that overexpression of tropomyosin receptor kinase A (TrkA) promotes the survival and Schwann cell-like differentiation of bone marrow stromal stem cells in nerve grafts, thereby enhancing the regeneration and functional ...
Mei-Ge Zheng, Wen-Yuan Sui, Zhen-Dan He, Yan Liu, Yu-Lin Huang, Shu-Hua Mu, Xin-Zhong Xu, Ji-Sen Zhang, Jun-Le Qu, Jian Zhang, Dong Wang   +10 more
doaj   +2 more sources

Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

FASEB BioAdvances, 2020
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck   +7 more
doaj   +2 more sources

Ganoderma Spore Lipids Inhibit Perineural Invasion in Pancreatic Cancer by Downregulating NGF-TrkA Pathway [PDF]

Journal of Evidence-Based Integrative Medicine
Perineural invasion (PNI) is an important factor leading to the recurrence of pancreatic cancer (PanCa). The NGF–TrkA pathway is related to PNI progression. Ganoderma spore lipid (GSL) is a drug with anti-cancer properties.
Haohui Lin MS, Manhon Chung MD, Yi Yang MS, Li Zhang MS, Xiaohua Pan MD, Sa Cai MD, PhD, Yu Pan PhD   +6 more
doaj   +2 more sources

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [PDF]

Annals of the Rheumatic Diseases, 2015
Objectives Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain.
L. Nwosu, P. Mapp, V. Chapman, D. Walsh
semanticscholar   +3 more sources

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [PDF]

Arthritis Research & Therapy, 2016
BackgroundInflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA).
S. Ashraf, K. Bouhana, J. Pheneger, S. Andrews, D. Walsh   +4 more
semanticscholar   +6 more sources