Results 1 to 10 of about 36,447 (274)

Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats [PDF]

Stem Cell Research & Therapy, 2021
Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action remains unclear.
Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang, Limin Rong   +5 more
doaj   +2 more sources

Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [PDF]

Frontiers in Molecular Neuroscience, 2023
AimsHuntingtin-associated protein 1 (HAP1) is a neuronal protein closely associated with microtubules and might facilitate neurological function rehabilitation.
Li Miao, Li Miao, Li Miao, Sun Wan Qing, Lu Tao   +4 more
doaj   +2 more sources

Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins [PDF]

Scientific Reports
We designed Proteolysis Targeting Chimeras (PROTACs) to target Tropomyosin Receptor Kinase A (TRKA) and Rearranged during Transfection (RET) oncogenic proteins.
Marialuisa Moccia, Lingzhi Zhang, Zhengyu Wang, Minmin Wang, Giorgia Federico, Massimo Santoro, Hong-yu Li, Francesca Carlomagno   +7 more
doaj   +2 more sources

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

Nature Communications, 2020
TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ...
Yaping Pan, Liya Hu, Zhao Wang
exaly   +2 more sources

Changji'an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway. [PDF]

BMC Complement Med Ther
Ke W, Huang S, Zhu H, Tan Q, Li H, Liu D, Zheng F, Zhang S, Lei K, Tang H.   +9 more
europepmc   +3 more sources

NGF activates NFAT via the MEK1/2 pathway in PC12 cells

All Life, 2022
Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj   +1 more source

The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma

Cells, 2023
Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca, Veronica Zelli, Cristina Pellegrini, Michela Sebastiano, Rita Maccarone, Marco Clementi, Alessandro Chiominto, Pierdomenico Ruggeri, Ludovica Cardelli, Marianna Ruggieri, Maddalena Sbaffone, Maria-Concetta Fargnoli, Stefano Guadagni, Antonietta R. Farina, Andrew R. Mackay   +14 more
doaj   +1 more source

Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation.

PLoS Pathogens, 2022
Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma, Mythili Dileepan, Qinfeng Huang, Thu Phan, Wei-Shou Hu, Hinh Ly, Yuying Liang   +6 more
doaj   +1 more source

The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer

Biomolecules, 2020
The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M. Walker, Hubert Hondermarck, Sam Faulkner   +7 more
doaj   +1 more source

Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases

Scientific Reports, 2021
We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor. Based on a kinome scan, here we show that Pz-1 is also a potent (IC50 
Marialuisa Moccia, Donglin Yang, Naga Rajiv Lakkaniga, Brendan Frett, Nicholas McConnell, Lingtian Zhang, Annalisa Brescia, Giorgia Federico, Lingzhi Zhang, Paolo Salerno, Massimo Santoro, Hong-yu Li, Francesca Carlomagno   +12 more
doaj   +1 more source