Results 91 to 100 of about 34,874 (291)
American Journal of Alzheimers Disease & Other Dementias, 2019 Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer’s disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor ...
Xinhui Li +4 more
semanticscholar +1 more source
Characterization of an NGF–P-TrkA Retrograde-Signaling Complex and Age-Dependent Regulation of TrkA Phosphorylation in Sympathetic Neurons [PDF]
The Journal of Neuroscience, 1999 Nerve growth factor (NGF) is a target-derived trophic factor for developing sympathetic and cutaneous sensory neurons. NGF promotes growth and survival of neurons via activation of the receptor tyrosine kinase TrkA. We used compartmentalized cultures of sympathetic neurons to address the mechanism of NGF signaling from distal axons and terminals to ...
David D. Ginty, Brian A. Tsui-Pierchala
openaire +3 more sources
PLoS ONE, 2015 Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex.
Teruhisa Takagishi +11 more
doaj +1 more source
Neurosignals, 2016 Background: Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure.
You-Ming Fan +5 more
doaj +1 more source
Graded potential of neural crest to form cornea, sensory neurons and cartilage along the rostrocaudal axis [PDF]
, 2004 Neural crest cells arising from different rostrocaudal axial levels form different sets of derivatives as diverse as ganglia, cartilage and cornea. These variations may be due to intrinsic properties of the cell populations, different environmental ...
Bronner-Fraser, Marianne +2 more
core +2 more sources
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, EarlyView.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
BMC Gastroenterology, 2019 Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration.
Erika Kropf +5 more
doaj +1 more source
TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors [PDF]
, 1906 SummaryPrimary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits ...
Wheeler, Michael A. +6 more
core +1 more source
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source