Results 91 to 100 of about 35,994 (298)

TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors [PDF]

, 1906
SummaryPrimary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits ...
Wheeler, Michael A., Heffner, Danielle L., Kim, Suemin, Espy, Sarah M., Spano, Anthony J., Cleland, Corey L., Deppmann, Christopher D.   +6 more
core   +1 more source

Characterization of an NGF–P-TrkA Retrograde-Signaling Complex and Age-Dependent Regulation of TrkA Phosphorylation in Sympathetic Neurons [PDF]

The Journal of Neuroscience, 1999
Nerve growth factor (NGF) is a target-derived trophic factor for developing sympathetic and cutaneous sensory neurons. NGF promotes growth and survival of neurons via activation of the receptor tyrosine kinase TrkA. We used compartmentalized cultures of sympathetic neurons to address the mechanism of NGF signaling from distal axons and terminals to ...
David D. Ginty, Brian A. Tsui-Pierchala
openaire   +3 more sources

Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

PLoS ONE, 2015
Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex.
Teruhisa Takagishi, Masataka Oda, Michiko Kabura, Mie Kurosawa, Kaori Tominaga, Shiori Urano, Yoshibumi Ueda, Keiko Kobayashi, Toshihide Kobayashi, Jun Sakurai, Yutaka Terao, Masahiro Nagahama   +11 more
doaj   +1 more source

Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells

Neurosignals, 2016
Background: Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure.
You-Ming Fan, Qing-Yuan Huang, Yin-Ai Wu, Alan R. Harvey, Qi Cui, Yu-Qi Gao   +5 more
doaj   +1 more source

Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor

Journal of Biological Chemistry, 2019
Tropomyosin-receptor kinases (TRKs) are essential for the development of the nervous system. The molecular mechanism of TRKA activation by its ligand nerve growth factor (NGF) is still unsolved.
M. L. Franco, K. Nadezhdin, S. Goncharuk, K. Mineev, A. Arseniev, M. Vilar   +5 more
semanticscholar   +1 more source

Graded potential of neural crest to form cornea, sensory neurons and cartilage along the rostrocaudal axis [PDF]

, 2004
Neural crest cells arising from different rostrocaudal axial levels form different sets of derivatives as diverse as ganglia, cartilage and cornea. These variations may be due to intrinsic properties of the cell populations, different environmental ...
Bronner-Fraser, Marianne, Conrad, Gary W., Lwigale, Peter Y.   +2 more
core   +2 more sources

Updated insights into the molecular pathogenesis of canine atopic dermatitis

Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source

Role of NGF‐TrkA signaling in calcification of articular chondrocytes

The FASEB Journal, 2019
Nerve growth factor (NGF) is a key regulator of chronic osteoarthritic pain, but the exact targets of NGF action on human articular cartilage is unknown.
Yangzi Jiang, R. Tuan
semanticscholar   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources