Results 101 to 110 of about 34,874 (291)
Molecules and Cells, 2010 TrkA, a receptor for nerve growth factor, plays a crucial role in neuronal cell growth and differentiation. However, overactivation of TrkA signaling leads to cell death in various cell types. TrkA-mediated cell death shows some similarities to DNA damage-induced cell death.
Eun Joo Jung, Deok Ryong Kim
openaire +3 more sources
Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]
, 1999 Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core
Novel clinical trial designs emerging from the molecular reclassification of cancer
CA: A Cancer Journal for Clinicians, EarlyView.Abstract Next‐generation sequencing has revealed the disruptive reality that advanced/metastatic cancers have complex and individually distinct genomic landscapes, necessitating a rethinking of treatment strategies and clinical trial designs. Indeed, the molecular reclassification of cancer suggests that it is the molecular underpinnings of the disease,
Mina Nikanjam +4 more
wiley +1 more source
QS8: The Roles of the TrkA and p75NTR NGF Receptors in Corneal Wound Healing
Plastic and Reconstructive Surgery, Global Open, 2021 Purpose: The cornea is the window through which we see the world and is one of the most densely innervated structures in the body. Besides providing protective sensory input, corneal nerves have been postulated to stimulate limbal stem cells (LSCs ...
Kiana Tajdaran +5 more
doaj +1 more source
Glia, Volume 73, Issue 5, Page 905-927, May 2025.Main Points Ibudilast, a MIF and PDE inhibitor, preserves the form and function of the retina, especially bipolar cells, during excitotoxic damage. Ibudilast upregulates multiple signaling pathways, including mTOR, in damaged Müller glia and bipolar cells.
Sumaya Hamadmad +16 more
wiley +1 more source
International Journal of Molecular Sciences, 2017 Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is initially synthesized as a precursor, proNGF, which is the predominant form in the central nervous system.
Maria S. Ioannou, M. Fahnestock
semanticscholar +1 more source
Functional expression of TrkA receptors in hippocampal neurons
Journal of Neuroscience Research, 1998 Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NIH 3T3, COS, and PC12 cells.
Aibel, Lani +3 more
openaire +4 more sources
Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Journal of Pharmacological Sciences, 2008 As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose +14 more
doaj
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
Journal of Experimental & Clinical Cancer Research, 2018 Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA ...
Antonietta Rosella Farina +6 more
doaj +1 more source
Live or Let Die: CCM2 Provides the Link [PDF]
, 2009 TrkA receptors are well known for promoting neuronal cell survival. However, in some neuroblastic tumors, TrkA activation can instead induce apoptosis. In this issue of Neuron, Harel et al.
Gruber-Olipitz, Mariella +1 more
core +1 more source