Results 101 to 110 of about 35,994 (298)

Control of TrkA-Induced Cell Death by JNK Activation and Differential Expression of TrkA upon DNA Damage

Molecules and Cells, 2010
TrkA, a receptor for nerve growth factor, plays a crucial role in neuronal cell growth and differentiation. However, overactivation of TrkA signaling leads to cell death in various cell types. TrkA-mediated cell death shows some similarities to DNA damage-induced cell death.
Eun Joo Jung, Deok Ryong Kim
openaire   +3 more sources

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR

Frontiers in Molecular Neuroscience, 2023
IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration.
Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, Margaret Fahnestock   +5 more
doaj   +1 more source

β-Hydroxybutyrate Ameliorates Aβ-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells

American Journal of Alzheimers Disease & Other Dementias, 2019
Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer’s disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor ...
Xinhui Li, Zhipeng Zhan, Jingzhu Zhang, Fuyuan Zhou, L. An   +4 more
semanticscholar   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
wiley   +1 more source

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj  

Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies

Frontiers in Chemistry, 2023
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar, Nihal Abdelmoniem, Hisham A. Elrufaie, Alaa Edris, Hiba Ghaboosh, Mohanad A. Mahgoub, Elrashied A. E. Garelnabi, Wadah Osman, Wadah Osman, Asmaa E. Sherif, Asmaa E. Sherif, Ahmed Ashour, Ahmed Ashour, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Rawan Bafail, Sabrin R. M. Ibrahim, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Abdulrahim A. Alzain   +20 more
doaj   +1 more source

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Volume 77, Issue 6, Page 664-676, June 2025.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source