Results 11 to 20 of about 36,447 (274)

APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling [PDF]

The Journal of Neuroscience, 2011
The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a product of amyloid precursor protein (APP) processing, cause dementia. However, alterations of normal APP functions could contribute to AD pathogenesis, and it is therefore important to understand the role of APP.
Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L.   +8 more
openaire   +6 more sources

TrkA Co-Receptors: The Janus Face of TrkA?

Cancers, 2023
Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon   +2 more
openaire   +3 more sources

Optical Activation of TrkA Signaling [PDF]

ACS Synthetic Biology, 2018
AbstractNerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer’s disease, chronic pain, inflammation, and cancer.
Liting Duan, Jen M. Hope, Shunling Guo, Qunxiang Ong, Amaury François, Luke Kaplan, Grégory Scherrer, Bianxiao Cui   +7 more
openaire   +3 more sources

NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]

PLoS ONE, 2012
Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor, Gretchen McCaffrey, Lindsay R Young, Mark L Grimes   +3 more
doaj   +1 more source

C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma

Oncogenesis, 2022
Neuroblastoma (NB) is a childhood tumor derived from the sympathoadrenal lineage of the neural crest progenitor cells. Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation, and its altered expression ...
Neng-Yu Lin, Syue-Ting Chen, Hsiu-Ling Chang, Meng-Yao Lu, Yung-Li Yang, Shu-Wei Chou, Dong-Tsamn Lin, Kai-Hsin Lin, Shiann-Tarng Jou, Wen-Ming Hsu, Min-Chuan Huang, Hsiu-Hao Chang   +11 more
doaj   +1 more source

Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2022
Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon   +20 more
doaj   +1 more source

Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA

Molecular Therapy: Methods & Clinical Development, 2023
Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli, Bonnie L. Hall, Mingdi Zhang, William F. Goins, Justus B. Cohen, Joseph C. Glorioso   +5 more
doaj   +1 more source

TrkA inhibition alleviates bladder overactivity in cyclophosphamide-induced cystitis by targeting hyperpolarization-activated cyclic nucleotide-gated channels [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To investigate the potential of Tropomyosin receptor kinase A (TrkA) for the treatment of interstitial cystitis/ bladder pain syndrome (IC/BPS).Materials and Methods: Sixty-four female rats were randomly assigned to the control and ...
Qian Liu, Xiaodong Li, Jingzhen Zhu, Bishao Sun, Shadan Li   +4 more
doaj   +1 more source

Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]

, 2006
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol, Djouhri, Laiche, Fang, Xin, Dr., Lawson, Sally N., McMullan, Simon, Okuse, Kenji, Waxman, Stephen G.   +6 more
core   +1 more source

Correlation of Nerve Growth Factor and Its Receptors Expression with Perineural Invasion in Early-stage Cervical Cancer

Zhongliu Fangzhi Yanjiu, 2018
Objective To evaluate the potential association of nerve growth factor (NGF) and its receptors TrkA and p75NRT with perineural invasion(PNI) and other clinicopathological features of early-stage cervical cancer.
LONG Ying, YAO Desheng, WEI Yousheng, WU Guangteng, DONG Tingting, FENG Yiming   +5 more
doaj   +1 more source