Results 11 to 20 of about 34,874 (291)

NGS-MRD negativity in post-HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk. [PDF]

Hemasphere
Abstract Monitoring of minimal residual disease (MRD) after hematopoietic stem cell transplantation (HSCT) in patients with acute lymphoblastic leukemia (ALL) is vital for timely therapeutic intervention planning. However, interpreting low‐positive results from the current standard method, quantitative PCR (qPCR) of immunoglobulin and T‐cell receptor ...
Seferna K, Svaton M, Rennerova A, Skotnicova A, Reznickova L, Valova T, Sedlacek P, Riha P, Formankova R, Keslova P, Sramkova L, Stary J, Zuna J, Kolenova A, Salek C, Trka J, Fronkova E.   +16 more
europepmc   +2 more sources

TrkA alternative splicing [PDF]

Cancer Cell, 2004
We identify a novel alternative TrkA splice variant, TrkAIII, with deletion of exons 6, 7, and 9 and functional extracellular IG-C1 and N-glycosylation domains, that exhibits expression restricted to undifferentiated early neural progenitors, human neuroblastomas (NBs), and a subset of other neural crest-derived tumors. This NGF-unresponsive isoform is
Antonella Tacconelli, Antonietta R. Farina, Lucia Cappabianca, Giuseppina DeSantis, Alessandra Tessitore, Antonella Vetuschi, Roberta Sferra, Nadia Rucci, Beatrice Argenti, Isabella Screpanti, Alberto Gulino, Andrew R. Mackay   +11 more
openalex   +8 more sources

Nerve Growth Factor Receptor (NGFR/p75NTR) of the Small-Spotted Catshark (Scyliorhinus canicula): Evolutionary Conservation and Brain Function. [PDF]

J Comp Neurol
p75NTR expression in the brain of the basal vertebrate Scyliorhinus canicula revealed its conservation across species. Functional conservation among vertebrates was demonstrated (i) by performing the canonical PC‐12 differentiation assay with the S. canicula NGF and (ii) by complementing the p75NTR absence in a PC‐12 p75NTR−/− knock‐out clone with the ...
Chiavacci E, Camera R, Costa M, Fronte B, Tozzini ET, Cellerino A.   +5 more
europepmc   +2 more sources

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. [PDF]

PLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravanis   +8 more
doaj   +4 more sources

APPL1 Associates with TrkA and GIPC1 and is Required for Nerve Growth Factor-Mediated Signal Transduction [PDF]

, 2006
The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein.
Bell, A., Brewer, N. E., Grimes, Mark L., Kaplan, D. R., Lin, D. C., Miller, F. D., Quevedo, C., Testa, J. R.   +7 more
core   +3 more sources

Biogenesis and function of the NGF/TrkA signaling endosome. [PDF]

International Review of Cell and Molecular Biology, 2015
Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons. In recent years, the signaling endosome model has been used to describe the sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde ...
M. Marlin, Guangpu Li
semanticscholar   +4 more sources

APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling [PDF]

The Journal of Neuroscience, 2011
The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a product of amyloid precursor protein (APP) processing, cause dementia. However, alterations of normal APP functions could contribute to AD pathogenesis, and it is therefore important to understand the role of APP.
Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L.   +8 more
openaire   +7 more sources

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Nature Communications, 2021
Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells.
Seungyong Lee, Charles D. Hwang, S. Marini, R. Tower, Q. Qin, S. Negri, Chase A. Pagani, Yuxiao Sun, David M. Stepien, M. Sorkin, Carrie A. Kubiak, Noelle D. Visser, C. Meyers, Yiyun Wang, Husain A. Rasheed, Jiajia Xu, Sarah Miller, A. Huber, L. Minichiello, P. Cederna, Stephen W. P. Kemp, T. Clemens, A. James, B. Levi   +23 more
semanticscholar   +1 more source

TrkA Co-Receptors: The Janus Face of TrkA?

Cancers, 2023
Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon   +2 more
openaire   +3 more sources

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

Brain : a journal of neurology, 2021
Early degeneration of basal forebrain cholinergic neurons contributes substantially to cognitive decline in Alzheimer’s disease. Evidence from preclinical models of neuronal injury and aging support a pivotal role for nerve growth factor (NGF) in ...
Kristiana Xhima, K. Markham-Coultes, R. H. Kofoed, H. U. Saragovi, K. Hynynen, I. Aubert   +5 more
semanticscholar   +1 more source