Results 11 to 20 of about 35,994 (298)
Optical activation of TrkA signaling [PDF]
ACS Synthetic Biology, 2018 Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer’s disease, chronic pain ...
Liting Duan +7 more
semanticscholar +6 more sources
GM1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA [PDF]
Journal of Neurochemistry, 2019 Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA–GM1 oligosaccharide complex at the cell surface.
E. Chiricozzi +9 more
semanticscholar +4 more sources
APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling [PDF]
The Journal of Neuroscience, 2011 The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a product of amyloid precursor protein (APP) processing, cause dementia. However, alterations of normal APP functions could contribute to AD pathogenesis, and it is therefore important to understand the role of APP.
Matrone C +8 more
openaire +7 more sources
Expression of NGF/proNGF and Their Receptors TrkA, p75NTR and Sortilin in Melanoma
International Journal of Molecular Sciences, 2022 There is increasing evidence that nerve growth factor (NGF) and its receptors, the neurotrophic receptor tyrosine kinase 1 (NTRK1/TrkA), the common neurotrophin receptor (NGFR/p75NTR) and the membrane receptor sortilin, participate in cancer growth.
Mark Marsland +7 more
semanticscholar +1 more source
TrkA Co-Receptors: The Janus Face of TrkA?
Cancers, 2023 Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez +2 more
openaire +3 more sources
International Journal of Molecular Sciences, 2022 Tropomyosin receptor kinase A (TrkA/NTRK1) is a high-affinity receptor for nerve growth factor (NGF), a potent pain mediator. NGF/TrkA signaling elevates synovial sensory neuronal distributions in the joints and causes osteoarthritis (OA) pain.
I. O-Sullivan +11 more
semanticscholar +1 more source
Nature Communications, 2021 Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells.
Seungyong Lee +23 more
semanticscholar +1 more source
Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies
Brain : a journal of neurology, 2021 Early degeneration of basal forebrain cholinergic neurons contributes substantially to cognitive decline in Alzheimer’s disease. Evidence from preclinical models of neuronal injury and aging support a pivotal role for nerve growth factor (NGF) in ...
Kristiana Xhima +5 more
semanticscholar +1 more source
Psychiatria Danubina, 2021 BACKGROUND Suicide Attempts are the main complications of Major Depressive Episodes and are difficult to predict. There is still a lack of knowledge about its neurochemical aspects.
L. Erbay +4 more
semanticscholar +1 more source
NGF activates NFAT via the MEK1/2 pathway in PC12 cells
All Life, 2022 Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj +1 more source