Results 21 to 30 of about 35,994 (298)
Cells, 2023 Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca +14 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, 2021 The current study aimed to investigate the mechanism by which miR‐454 influences the progression of heart failure (HF) in relation to the neural precursor cell expressed, developmentally downregulated 4‐2 (NEDD4‐2)/tropomyosin receptor kinase A (TrkA ...
Yaowen Wang +5 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Breast cancer is the leading cancer in American women. Due to the inherent aggressiveness of triple-negative and HER2-enriched breast cancers, it is imperative to identify novel molecular targets for therapeutic intervention.
Angelina T Regua +17 more
semanticscholar +1 more source
Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling [PDF]
Biochemical Journal, 2004 The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling molecules are compartmentalized. The response to NGF (nerve growth factor) is strongly dependent on the trafficking of its receptor, TrkA.
Lucio Nitsch +6 more
openaire +5 more sources
NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]
PLoS ONE, 2012 Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor +3 more
doaj +1 more source
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases
Scientific Reports, 2021 We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor. Based on a kinome scan, here we show that Pz-1 is also a potent (IC50
Marialuisa Moccia +12 more
doaj +1 more source
PLoS Pathogens, 2022 Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma +6 more
doaj +1 more source
GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling [PDF]
Molecular and Cellular Biology, 2006 GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here that endogenous GIPC binds to the C terminus of APPL, a Rab5 binding protein, which is a marker for signaling endosomes.
Hyacynth Gacula +9 more
openaire +4 more sources
TrkA alternative splicing [PDF]
Cancer Cell, 2004 We identify a novel alternative TrkA splice variant, TrkAIII, with deletion of exons 6, 7, and 9 and functional extracellular IG-C1 and N-glycosylation domains, that exhibits expression restricted to undifferentiated early neural progenitors, human neuroblastomas (NBs), and a subset of other neural crest-derived tumors. This NGF-unresponsive isoform is
Antonella Tacconelli +11 more
openalex +8 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez +20 more
doaj +1 more source