Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Scientific Reports, 2023 Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA
Ashley J. Mason +4 more
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
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Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
eLife, 2018 The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye +2 more
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Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice [PDF]
The Journal of Neuroscience, 1995 Experiments over the past decade in which NGF/TrkA signaling has been abolished by antibodies or targeted gene mutations have shown that 70- 85% of dorsal root ganglion (DRG) neurons require NGF for survival during development. There is consensus that many of the NGF-dependent neurons are small-diameter, peptidergic neurons subserving nociception ...
I, Silos-Santiago +6 more
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ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]
, 2017 To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De +9 more
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Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling [PDF]
Biochemical Journal, 2004 The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling molecules are compartmentalized. The response to NGF (nerve growth factor) is strongly dependent on the trafficking of its receptor, TrkA.
Perrone L. +5 more
openaire +4 more sources
Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Journal of Pharmacological Sciences, 2008 As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose +14 more
doaj +1 more source
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
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A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]
, 2016 The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine +20 more
core +1 more source
Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Frontiers in Molecular Neuroscience, 2023 Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique +9 more
doaj +1 more source