Results 21 to 30 of about 34,874 (291)
Journal of Cellular and Molecular Medicine, 2021 The current study aimed to investigate the mechanism by which miR‐454 influences the progression of heart failure (HF) in relation to the neural precursor cell expressed, developmentally downregulated 4‐2 (NEDD4‐2)/tropomyosin receptor kinase A (TrkA ...
Yaowen Wang +5 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Breast cancer is the leading cancer in American women. Due to the inherent aggressiveness of triple-negative and HER2-enriched breast cancers, it is imperative to identify novel molecular targets for therapeutic intervention.
Angelina T Regua +17 more
semanticscholar +1 more source
NGF activates NFAT via the MEK1/2 pathway in PC12 cells
All Life, 2022 Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj +1 more source
Cells, 2023 Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca +14 more
doaj +1 more source
Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems
Developmental Dynamics, Volume 252, Issue 1, Page 81-103, January 2023., 2023 Abstract Sensory neurons of the head are the ones that transmit the information about the external world to our brain for its processing. Axons from cranial sensory neurons sense different chemoattractant and chemorepulsive molecules during the journey and in the target tissue to establish the precise innervation with brain neurons and/or receptor ...
Gemma Nomdedeu‐Sancho, Berta Alsina
wiley +1 more source
Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity
Journal of Orthopaedic Research, Volume 41, Issue 2, Page 316-324, February 2023., 2023 Abstract Nerve growth factor (NGF) is a neurotrophin that has been implicated in pain signaling, apoptosis, inflammation and proliferation. The resultant effects depend on interaction with two different receptors; tyrosine kinase A (TrkA) and p75NTR. NGF increases in synovial fluid from osteoarthritic joints, and monoclonal antibody therapy is trialed ...
Anna Kendall +2 more
wiley +1 more source
Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling [PDF]
Biochemical Journal, 2004 The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling molecules are compartmentalized. The response to NGF (nerve growth factor) is strongly dependent on the trafficking of its receptor, TrkA.
Lucio Nitsch +6 more
openaire +7 more sources
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases
Scientific Reports, 2021 We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor. Based on a kinome scan, here we show that Pz-1 is also a potent (IC50
Marialuisa Moccia +12 more
doaj +1 more source
GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling [PDF]
Molecular and Cellular Biology, 2006 GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here that endogenous GIPC binds to the C terminus of APPL, a Rab5 binding protein, which is a marker for signaling endosomes.
Hyacynth Gacula +9 more
openaire +4 more sources
PLoS Pathogens, 2022 Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma +6 more
doaj +1 more source