Results 51 to 60 of about 30,031 (261)

One at a time, live tracking of NGF axonal transport using quantum dots [PDF]

, 2007
Retrograde axonal transport of nerve growth factor (NGF) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons.
A. Ramirez, B. Cui, Beattie, Bhattacharyya, Bomont, Bonneau, Bronfman, C. Wu, Campenot, Chan, Claude, Delcroix, E. L. Bearer, Fu, Giepmans, Ginty, Grimes, Hohng, Howe, Korsching, Kuruvilla, L. Chen, Lidke, Miller, Mobley, Pinaud, Reynolds, Reynolds, Rosenberg, S. Chu, Salehi, Sofroniew, Tani, Taylor, Ure, Valdez, von Bartheld, Vu, W. C. Mobley, W.-P. Li, Watson, Weible, Wu, Ye, Zhuang, Zweifel   +45 more
core   +3 more sources

NGF – the TrkA to successful pain treatment

Journal of Pain Research, 2012
Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. Specifically, since the underlying cause of these pain syndromes is unknown or heterogeneous, physicians diagnose and treat ...
Kumar, Vinayak, Mahal, Brandon
openaire   +4 more sources

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano, Takuma Matoba, Daisuke Kawakita, Kiyoshi Minohara, Sho Iwaki, Hiroshi Tsuge, Koji Tsukamoto, Sekai Kikuchi, Satsuki Nakano, Takayuki Murase, Yuichiro Tada, Shinichi Iwasaki   +11 more
wiley   +1 more source

Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 2001
Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core  

Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA

Molecular Therapy: Methods & Clinical Development, 2023
Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli, Bonnie L. Hall, Mingdi Zhang, William F. Goins, Justus B. Cohen, Joseph C. Glorioso   +5 more
doaj  

NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment

BMC Neuroscience, 2020
Background Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) receptors, are involved in neuronal
Ting Yan, Zhihui Zhang, Danqing Li
doaj   +1 more source

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

Chemistry & Biology, 2009
Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation.
Jang, Sung Wuk, Liu, Xia, Chan, Chi Bun, Weinshenker, David, Hall, Randy A., Xiao, Ge, Ye, Keqiang   +6 more
openaire   +5 more sources

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen‐activated protein kinase (MAPK) and extracellular signal‐regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood.
Akanksha Nagarkar, Jackson Turbeville, Molly A. Hinshaw, Philip E. LeBoit, Jeffrey Gagan, Mark Raffeld, Kenneth Aldape, Niharika Shah, Frederic G. Barr, Liqiang Xi, Ina Lee, Christina K. Ferrone, Svetlana D. Pack, Rosandra Kaplan, Mary Frances Wedekind Malone, Marielle Yohe, Michael R. Sargen   +16 more
wiley   +1 more source