Results 81 to 90 of about 35,994 (298)
Head &Neck, EarlyView.ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano +11 more
wiley +1 more source
Frontiers in Oncology, 2019 Pediatric cancers represent a wide variety of different tumors, though they have unique features that distinguish them from adult cancers. Receptor tyrosine kinases KIT and TrkA functions in AML and NB, respectively, are well-characterized.
T. Lebedev +5 more
semanticscholar +1 more source
Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]
, 1998 Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core
On the Shape of Things: From holography to elastica [PDF]
, 2017 We explore the question of which shape a manifold is compelled to take when immersed in another one, provided it must be the extremum of some functional.
Fonda, Piermarco +2 more
core +3 more sources
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Multiple imputation is increasingly being used to deal with missing data in clinical trials. It is a simulation approach leading to multiple analyses of a pre‐defined number of datasets. For a pre‐defined statistical model, this is relatively straightforward, but for model development as typically conducted in Pharmacometrics, it is unclear ...
Martin Boucher +2 more
wiley +1 more source
Chemistry & Biology, 2009 Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation.
Jang, Sung Wuk +6 more
openaire +5 more sources
PLoS Biology, 2011 The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis +8 more
doaj +1 more source
Expression of NGF, Trka and p75 in human cartilage
European Journal of Histochemistry, 2009 Nerve growth factor (NGF) exerts its action through two types of receptor: high-affinity tyrosine kinase A receptor (trkA) and low-affinity p75 receptor. NGF has a neurotrophic role in central and peripheral nervous system development, but there is also clear evidence of its involvement in the developing skeleton.
Gigante, A. +5 more
openaire +6 more sources
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, EarlyView.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma
Molecular Oncology, 2017 Nucleophosmin‐anaplastic lymphoma kinase‐expressing (NPM‐ALK+) T‐cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM‐ALK+ T‐cell lymphoma is not completely understood.
Wenyu Shi +6 more
doaj +1 more source