Results 41 to 50 of about 68,245 (107)

Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

eLife
Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA synthesis by commonly used reverse transcriptases ...
Hans Tobias Gustafsson, Lucas Ferguson, Carolina Galan, Tianxiong Yu, Heather Upton, Ebru Kaymak, Zhiping Weng, Kathleen Collins, Oliver J Rando   +8 more
doaj   +1 more source

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Molecular Cancer, 2023
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer.
Raquel García-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa García-Longarte, Amaia Zabala-Letona, Ianire Astobiza, Sonia Fernández, Alejandro Paniagua, Borja Miguel-López, Virginie Marchand, Diego Alonso-López, Angelika Merkel, Ignacio García-Tuñón, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M. Aransay, Tomás Di Domenico, Manuel A. Sánchez-Martín, Javier De Las Rivas, Sònia Guil, Yuri Motorin, Mark Helm, Pier Paolo Pandolfi, Arkaitz Carracedo, Sandra Blanco   +36 more
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Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution

Life, 2015
Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
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Unravelling tRNA fragments in DENV pathogenesis: Insights from RNA sequencing

Scientific Reports
Small non-coding RNAs (sncRNAs) derived from tRNAs are known as tRNA-derived small RNAs (tsRNAs). These tsRNAs are further categorized into tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), which play significant roles in the various molecular ...
Deeksha Madhry, Kiran Kumari, Varsha Meena, Riya Roy, Bhupendra Verma   +4 more
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Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

Molecular Cancer, 2020
One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB).
Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu, Changcheng Zhou, Kenneth S. Knox, Ting Wang, Qi Chen, Zhongqing Qian, Tong Zhou   +21 more
doaj   +1 more source

Mapping the small RNA content of simian immunodeficiency virions (SIV).

PLoS ONE, 2013
Recent evidence indicates that regulatory small non-coding RNAs are not only components of eukaryotic cells and vesicles, but also reside within a number of different viruses including retroviral particles.
Markus Brameier, Wiebke Ibing, Katharina Höfer, Judith Montag, Christiane Stahl-Hennig, Dirk Motzkus   +5 more
doaj   +1 more source

SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs

Genomics, Proteomics & Bioinformatics, 2018
High-throughput RNA-seq has revolutionized the process of small RNA (sRNA) discovery, leading to a rapid expansion of sRNA categories. In addition to the previously well-characterized sRNAs such as microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and ...
Junchao Shi, Eun-A Ko, Kenton M. Sanders, Qi Chen, Tong Zhou   +4 more
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A Novel tsRNA, m7G‐3′ tiRNA LysTTT, Promotes Bladder Cancer Malignancy Via Regulating ANXA2 Phosphorylation

Advanced Science
Emerging evidence indicates that transfer RNA (tRNA)‐derived small RNAs (tsRNAs), originated from tRNA with high abundance RNA modifications, play an important role in many complex physiological and pathological processes.
Xiaoling Ying, Wenyu Hu, Yapeng Huang, Yifan Lv, Ding Ji, Cong Chen, Baotong Yang, Chengcheng Zhang, Yaomin Liang, Haiqing Zhang, Mingrui Liu, Gang Yuan, Wenqi Wu, Weidong Ji   +13 more
doaj   +1 more source

Description of plant tRNA-derived RNA fragments (tRFs) associated with argonaute and identification of their putative targets

Biology Direct, 2013
tRNA-derived RNA fragments (tRFs) are 19mer small RNAs that associate with Argonaute (AGO) proteins in humans. However, in plants, it is unknown if tRFs bind with AGO proteins.
Loss-Morais Guilherme, Waterhouse Peter M, Margis Rogerio   +2 more
doaj   +1 more source

Deciphering the contribution of 5’-tiRNA- Lys-CTT as an emerging early diagnostic biomarker for hepatocellular carcinoma

Discover Oncology
Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide, with early detection critical for improving survival rates. Late-stage diagnosis contributes to dismal prognosis.
Abinash Nayak
doaj   +1 more source