Results 31 to 40 of about 68,245 (107)

tRNA cleavage: a new insight

Neural Regeneration Research, 2020
Over the past decades, tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others, holding more than half of all modifications occurring in RNA molecules.
Sherif Rashad, Kuniyasu Niizuma, Teiji Tominaga   +2 more
doaj   +1 more source

ITAS: Integrated Transcript Annotation for Small RNA

Non-Coding RNA, 2022
Transcriptomics analysis of various small RNA (sRNA) biotypes is a new and rapidly developing field. Annotations for microRNAs, tRNAs, piRNAs and rRNAs contain information on transcript sequences and loci that is vital for downstream analyses.
Alexey Stupnikov, Vitaly Bezuglov, Ivan Skakov, Victoria Shtratnikova, J. Richard Pilsner, Alexander Suvorov, Oleg Sergeyev   +6 more
doaj   +1 more source

Characterization of novel small non-coding RNAs and their modifications in bladder cancer using an updated small RNA-seq workflow

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer (BLCA) is one of the most common cancer types worldwide. The disease is responsible for about 200,000 deaths annually, thus improved diagnostics and therapy is needed.
Zhangli Su, Zhangli Su, Ida Monshaugen, Ida Monshaugen, Ida Monshaugen, Arne Klungland, Arne Klungland, Rune Ougland, Rune Ougland, Anindya Dutta, Anindya Dutta   +10 more
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Research progress on the tsRNA classification, function, and application in gynecological malignant tumors

Cell Death Discovery, 2021
A large number of small non-coding RNAs derived from tRNAs, called tRNA-derived small RNA (tsRNAs), have been identified by high-throughput RNA sequencing of cell lines. Further research has revealed that they are not produced via random tRNA degradation,
Jing-tao Wen, Zheng-hao Huang, Qian-hui Li, Xi Chen, Hong-lei Qin, Yang Zhao   +5 more
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The epitranscriptome of small non-coding RNAs

Non-coding RNA Research, 2021
Small non-coding RNAs are short RNA molecules and involved in many biological processes, including cell proliferation and differentiation, immune response, cell death, epigenetic regulation, metabolic control.
Xiaoyu Li, Jinying Peng, Chengqi Yi
doaj   +1 more source

Role of tRNA-Derived Fragments in Protozoan Parasite Biology

Cells
tRNA molecules are among the most fundamental and evolutionarily conserved RNA types, primarily facilitating the translation of genetic information from mRNA into proteins.
Manu Sharma, Upinder Singh
doaj   +1 more source

The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review

Pharmacological Research
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs (tiRNAs).
Kai Wang, Cui-Yun Liu, Bo Fang, Bo Li, Ying-Hui Li, Qian-Qian Xia, Yan Zhao, Xue-Li Cheng, Su-Min Yang, Mei-Hua Zhang, Kun Wang   +10 more
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Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review

Frontiers in Cell and Developmental Biology
tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs(ncRNAs) generated from precursor or mature tRNAs under stress conditions, such as starvation, hypoxia, or oxidative stress.
Qian Zhou, Qian Zhou, Qian Zhou, Qian Zhou, Minxin He, Minxin He, Minxin He, Minxin He, Min Liu, Guoying Sun, Guoying Sun, Guoying Sun, Guoying Sun, Jian Li, Jian Li, Jian Li, Jian Li   +16 more
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Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Genes and Diseases
With the development of sequencing technology, transfer RNA (tRNA)-derived small RNAs (tsRNAs) have received extensive attention as a new type of small noncoding RNAs.
Yu Zhang, Xinliang Gu, Yang Li, Yuejiao Huang, Shaoqing Ju   +4 more
doaj   +1 more source

Host tRNA-Derived RNAs Target the 3′Untranslated Region of SARS-CoV-2

Pathogens, 2022
The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as ...
Emily N. Hendrickson, Marna E. Ericson, Lynne T. Bemis   +2 more
doaj   +1 more source