Results 21 to 30 of about 68,245 (107)

Global survey of miRNAs and tRNA-derived small RNAs from the human parasitic protist Trichomonas vaginalis

Parasites & Vectors, 2021
Background Small non-coding RNAs play critical regulatory roles in post-transcription. However, their characteristics in Trichomonas vaginalis, the causative agent of human sexually transmitted trichomoniasis, still remain to be determined. Methods Small
Zhen-Sheng Wang, Hong-Chang Zhou, Chun-Yan Wei, Zhi-Hua Wang, Xiao Hao, Lian-Hui Zhang, Jing-Zhong Li, Zeng-Lei Wang, Heng Wang   +8 more
doaj   +1 more source

High Expression of a tRNA^Pro Derivative Associates with Poor Survival and Independently Predicts Colorectal Cancer Recurrence

Biomedicines, 2022
Colorectal cancer (CRC) is the second most lethal cause of cancer-related deaths in Europe. Fragments of tRNAPro are conserved among vertebrates, characterized by pleiotropic regulatory functions and have been found to discriminate colorectal tumors from
Panagiotis Tsiakanikas, Panagiotis G. Adamopoulos, Dimitra Tsirba, Pinelopi I. Artemaki, Iordanis N. Papadopoulos, Christos K. Kontos, Andreas Scorilas   +6 more
doaj   +1 more source

Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves

mBio, 2023
tRNA-derived fragments have been reported in many different organisms and have diverse cellular roles, such as regulating gene expression, inhibiting protein translation, silencing transposable elements, and modulating cell proliferation.
Manu Sharma, Hanbang Zhang, Gretchen Ehrenkaufer, Upinder Singh   +3 more
doaj   +1 more source

Pathological significance of tRNA-derived small RNAs in neurological disorders

Neural Regeneration Research, 2020
Non-coding RNAs (ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs (tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells.
Chuan Qin, Pei-Pei Xu, Xin Zhang, Chao Zhang, Chang-Bin Liu, De-Gang Yang, Feng Gao, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li   +9 more
doaj   +1 more source

The emerging role of small non-coding RNA in renal cell carcinoma

Translational Oncology, 2021
Noncoding RNAs are transcribed in the most regions of the human genome, divided into small noncoding RNAs (less than 200 nt) and long noncoding RNAs (more than 200 nt) according to their size.
Lifeng Ding, Minxiao Jiang, Ruyue Wang, Danyang Shen, Huan Wang, Zeyi Lu, Qiming Zheng, Liya Wang, Liqun Xia, Gonghui Li   +9 more
doaj   +1 more source

The Small RNA Component of Arabidopsis thaliana Phloem Sap and Its Response to Iron Deficiency

Plants, 2023
In order to discover sRNA that might function during iron deficiency stress, RNA was prepared from phloem exudates of Arabidopsis thaliana, and used for RNA-seq. Bioanalyzer results indicate that abundant RNA from phloem is small in size—less than 200 nt.
Ahmet Bakirbas, Rosario Castro-Rodriguez, Elsbeth L. Walker   +2 more
doaj   +1 more source

Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle

Frontiers in Genetics, 2015
The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas, Guohong eCai, John D. Neill   +2 more
doaj   +1 more source

tRNA-derived small RNAs: Mechanisms and potential roles in cancers

Genes and Diseases, 2022
Transfer RNAs (tRNAs) are essential for protein synthesis. Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs (tsRNAs). tsRNAs, divided into tRNA-derived stress-induced RNA (tiRNAs) and tRNA-derived fragments (tRFs), play versatile ...
Yao Wang, Qiuyan Weng, Jiaxin Ge, Xinjun Zhang, Junming Guo, Guoliang Ye   +5 more
doaj   +1 more source

The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases

Biology
Transfer RNA is a class of non-coding RNA that plays a role in amino acid translocation during protein synthesis. After specific modification, the cleaved fragment is called tRNA-derived small RNA.
Jiaxu Guo, Xinzhe Chen, Jiahao Ren, Yunhong Wang, Kun Wang, Sumin Yang   +5 more
doaj   +1 more source

Presence and diagnostic value of circulating tsncRNA for ovarian tumor

Molecular Cancer, 2018
tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional
Eric Y. Peng, Yang Shu, Yuke Wu, Feier Zeng, Shuangyan Tan, Yun Deng, Yiqi Deng, Haining Chen, Lei Zhu, Heng Xu   +9 more
doaj   +1 more source