Results 11 to 20 of about 68,245 (107)
Identification of tRNA-derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer. [PDF]
J Cell Physiol, 2020 Farina NH +11 more
europepmc +2 more sources
tRFs and tRNA Halves: Novel Cellular Defenders in Multiple Biological Processes
Current Issues in Molecular Biology, 2022 tRNA fragments derived from angiogenin or Dicer cleavage are referred to as tRNA-derived fragments (tRFs) and tRNA halves. tRFs and tRNA halves have been identified in both eukaryotes and prokaryotes and are precisely cleaved at specific sites on either ...
Jiani Hou +3 more
doaj +1 more source
Journal of Lipid Research, 2023 Small noncoding RNAs (sncRNAs) play diverse roles in numerous biological processes. While the widely used RNA sequencing (RNA-Seq) method has advanced sncRNA discovery, RNA modifications can interfere with the complementary DNA library construction ...
Rebecca Hernandez +8 more
doaj +1 more source
Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA [PDF]
ExRNA, 2019 The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-
Fangfang Jin, Zhigang Guo
doaj +1 more source
Function and Therapeutic Implications of tRNA Derived Small RNAs
Frontiers in Molecular Biosciences, 2022 tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from ...
Briana Wilson, Anindya Dutta
doaj +1 more source
Transfer RNAs-derived small RNAs and their application potential in multiple diseases
Frontiers in Cell and Developmental Biology, 2022 The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular ...
Xiaohua Chu +7 more
doaj +1 more source
tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases
Kidney Diseases, 2023 Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li +6 more
doaj +1 more source
Small RNA modifications: regulatory molecules and potential applications
Journal of Hematology & Oncology, 2023 Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells.
Qunli Xiong, Yaguang Zhang
doaj +1 more source
Cell Reports, 2013 Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic +4 more
doaj +1 more source
Scientific Reports, 2021 tRNAs and tRNA-derived RNA fragments (tRFs) play various roles in many cellular processes outside of protein synthesis. However, comprehensive investigations of tRNA/tRF regulation are rare.
Zefang Sun +16 more
doaj +1 more source