Results 41 to 50 of about 4,124 (226)
Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]
, 2013 The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani +58 more
core +9 more sources
Mechanism of actin filament pointed-end capping by tropomodulin [PDF]
Science, 2014 Making tropomodulin find the right point Actin filaments are a key component of the cell's cytoskeleton. Actin filaments have a characteristic polarized architecture with a so-called barbed end and a pointed end—so described because of how the filaments look under the electron microscope when they are coated with tropomyosin. Rao
Jampani Nageswara Rao +2 more
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Favorable prognostic role of tropomodulins in neuroblastoma [PDF]
Oncotarget, 2018 Neuroblastoma is a pediatric tumor of the sympatoadrenal lineage of the neural crest characterized by high molecular and clinical heterogeneity, which are the main causes of the poor response to standard multimodal therapy. The identification of new and selective biomarkers is important to improve our knowledge on the mechanisms of neuroblastoma ...
Paola Bettinsoli +6 more
openalex +4 more sources
Mutations changing tropomodulin affinity for tropomyosin alter neurite formation and extension [PDF]
PeerJ, 2013 Assembly of the actin cytoskeleton is an important part of formation of neurites in developing neurons. Tropomodulin, a tropomyosin-dependent capping protein for the pointed end of the actin filament, is one of the key players in this process ...
Natalia Moroz +3 more
doaj +2 more sources
Cytoplasmic Nuclear Transfer of the Actin-capping Protein Tropomodulin [PDF]
Journal of Biological Chemistry, 2004 Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers. We unexpectedly discovered significant levels of Tmod in nuclei and then defined peptide domains in Tmod responsible for ...
Kimi Kong, Larry Kedes
openalex +4 more sources
Identification of a Novel Tropomodulin Isoform, Skeletal Tropomodulin, That Caps Actin Filament Pointed Ends in Fast Skeletal Muscle [PDF]
Journal of Biological Chemistry, 1999 Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin filaments in striated muscle. Here, we describe the identification and characterization of a novel tropomodulin isoform, skeletal tropomodulin (Sk-Tmod) from chickens. Sk-Tmod is 62% identical in amino acid sequence to the previously
Angels Almenar‐Queralt +4 more
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Combinatorial chemistry & high throughput screening, 2023 Background Pancreatic adenocarcinoma (PAAD) is a frequent malignant tumor with a high mortality rate. Searching for novel biomarkers that can influence its prognosis may help patients.
W. Jin +7 more
semanticscholar +1 more source
Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia
Human Molecular Genetics, 2021 Tsering Stobdan +5 more
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Cardiac leiomodin2 binds to the sides of actin filaments and regulates the ATPase activity of myosin. [PDF]
PLoS ONE, 2017 Leiomodin proteins are vertebrate homologues of tropomodulin, having a role in the assembly and maintenance of muscle thin filaments. Leiomodin2 contains an N-terminal tropomodulin homolog fragment including tropomyosin-, and actin-binding sites, and a C-
Dávid Szatmári +5 more
doaj +1 more source
Development, 2023 Proper muscle contraction requires the assembly and maintenance of sarcomeres and myofibrils. While the protein components of myofibrils are generally known, less is known about the mechanisms by which they individually function and together synergize ...
Carolina Zapater i Morales +5 more
semanticscholar +1 more source