Results 51 to 60 of about 4,124 (226)

Tropomodulin binds to filensin intermediate filaments [PDF]

FEBS Letters, 2003
Tropomodulin (Tmod) is an actin filament pointed end capping protein found in the membrane skeleton of lens fiber cells. We demonstrate that Tmod4 is able to bind the lens‐specific intermediate filament protein, filensin, in either co‐sedimentation or solid phase binding assays in a saturable fashion, but with low affinity and stoichiometry ...
Fischer, R.S., Quinlan, R.A., Fowler, V.M.   +2 more
openaire   +2 more sources

Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts

Frontiers in Endocrinology, 2021
Insulin and muscle contractions mediate glucose transporter 4 (GLUT4) translocation and insertion into the plasma membrane (PM) for glucose uptake in skeletal muscles.
Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C. Robinson, Weiping Han, Weiping Han   +5 more
doaj   +1 more source

Effect of Chitosan Composite Preservative on Proteome Changes of Grass Carp Muscle during Cold Storage [PDF]

Shipin Kexue, 2023
To explore the effect of a chitosan-based preservative solution (10 mg/mL chitosan + 5 mg/mL tea polyphenol + 2 000 U/mL lysozyme) on the change in the muscle proteome of grass carp during cold storage, differential proteomic analysis of fresh fish and ...
LI Jialei, CHEN Sai, TIAN Mingli, YU Jian, LIU Yongle, WANG Faxiang
doaj   +1 more source

Drosophila Tropomodulin is required for multiple actin-dependent processes in myofiber assembly and maintenance

bioRxiv, 2022
Proper muscle contraction requires the assembly and maintenance of sarcomeres and myofibrils. While the protein components of myofibrils are generally known, less is known about the mechanisms by which they individually function and together synergize ...
Carolina Zapater i Morales, Peter J. Carman, David B. Soffar, S. Windner, R. Dominguez, M. Baylies   +5 more
semanticscholar   +1 more source

Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.

PLoS Biology, 2020
Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and maintenance; however, its role is under
Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova   +7 more
doaj   +1 more source

Tropomodulins are negative regulators of neurite outgrowth [PDF]

European Journal of Cell Biology, 2011
Regulation of the actin cytoskeleton is critical for neurite formation. Tropomodulins (Tmods) regulate polymerization at actin filament pointed ends. Previous experiments using a mouse model deficient for the neuron specific isoform Tmod2 suggested a role for Tmods in neuronal function by impacting processes underlying learning and memory. However, the
Fath, T., Fischer, R., Dehmelt, L., Halpain, S., Fowler, V.   +4 more
openaire   +3 more sources

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Tropomodulins and tropomyosins: working as a team [PDF]

Journal of Muscle Research and Cell Motility, 2013
Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, making their presence indispensable in living cells.
Colpan, Mert, Moroz, Natalia, Kostyukova, Alla   +2 more
openaire   +3 more sources

The transcriptional profile of iron deficiency in patients with heart failure: Heme-sparing and reduced immune processes. [PDF]

Eur J Heart Fail
The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Grote Beverborg N, Alnuwaysir RIS, Markousis-Mavrogenis G, Hoes MF, van der Wal HH, Romaine SPR, Nath M, Koekoemoer A, Cleland JGF, Lang CC, Anker SD, Dickstein K, Metra M, Ng LL, van Veldhuisen DJ, Voors AA, Samani NJ, van der Meer P.   +17 more
europepmc   +2 more sources

Functions of actin‐binding proteins in cilia structure remodeling and signaling

Biology of the Cell, Volume 115, Issue 11, November 2023., 2023
Wang et al. review recent progresses about roles of actin‐binding proteins (ABPs) in the regulation of cilia morphology and signaling including TGF‐β, Wnt, and Hedgehog signaling pathways. The dysregulation of ciliogenesis and ciliary signaling are closely linked with cilia‐related diseases such as polycystic kidney disease (PKD) and myocardial ...
Siqi Wang, Xin Wang, Congbin Pan, Ying Liu, Min Lei, Xiying Guo, Qingjie Chen, Xiaosong Yang, Changhan Ouyang, Zhanhong Ren   +9 more
wiley   +1 more source