Results 11 to 20 of about 6,673,815 (394)
Focus on cardiac troponin complex: From gene expression to cardiomyopathy [PDF]
Genes and DiseasesThe cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin ...
Rosetta Ragusa, Chiara Caselli
doaj +3 more sources
False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report [PDF]
European Heart Journal - Case Reports, 2020 Abstract Background Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease [‘classical’ myocardial infarction (MI)].
Paul Collinson +6 more
openaire +4 more sources
Proteins of the Troponin Complex [PDF]
Laboratory Medicine, 1992 The troponin complex is a group of three protein subunits located on the thin filament of the contractile apparatus. These three subunits—troponin T, troponin I, and troponin C—different in genetic and protein structure, act together to regulate muscle contraction.
A. Remppis +3 more
openaire +2 more sources
Clinical Biochemistry of Serum Troponin
DiagnosticsAccurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS).
Ilhan Gokhan +8 more
doaj +2 more sources
Dynamic Light Scattering from Semidilute Actin Solutions: A Study of Hydrodynamic Screening, Filament Bending Stiffness and the Effect of Tropomyosin/Troponin-Binding [PDF]
, 1995 Quasi-elastic light scattering (QELS) is applied to investigate the effect of the tropomyosin/troponin complex (Tm/Tn) on the stiffness of actin filaments. The importance of hydrodynamic screening in semidilute solutions is demonstrated. A new concentration dependent expression for the dynamic structure factor $g(\bm k,t)$ of semiflexible polymers in ...
Baermann, M. +4 more
arxiv +3 more sources
PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis. [PDF]
PLoS ONE, 2013 AIMS:Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a potential therapeutic target, however, the exact consequences for contractile function in human ...
Viola Kooij +12 more
doaj +2 more sources
Journal of Biological Chemistry, 1974 Abstract By means of new or modified procedures troponin-tropomyosin complex was fractionated into three components plus tropomyosin, and then reconstituted in the absence of urea. Tropomyosin was separated from troponin by hydroxyapatite column chromatography, a method giving sharper separation than the previously used technique of isoelectric ...
Evan Eisenberg, W. Wayne Kielley
openalex +4 more sources
Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics [PDF]
Nature Communications, 2023 Protein complexes are highly dynamic entities that display substantial diversity in their assembly, post-translational modifications, and non-covalent interactions, allowing them to play critical roles in various biological processes.
Emily A. Chapman +11 more
doaj +2 more sources
Journal of Biological Chemistry, 2009 Our previous studies (Howarth, J. W., Meller, J., Solaro, R. J., Trewhella, J., and Rosevear, P. R. (2007) J. Mol. Biol. 373, 706–722) of the unique N-terminal region of human cardiac troponin I (hcTnI), predicted a possible intramolecular interaction ...
Chad M. Warren +2 more
openalex +2 more sources
Dynamics of the C-Terminal Region of TnI in the Troponin Complex in Solution [PDF]
Biophysical Journal, 2006 The determination of crystal structures of the troponin complex (Takeda et al. 2003. Nature. 424:35-41; Vinogradova et al. 2005. Proc. Natl. Acad. Sci. USA.
Tharin M. A. Blumenschein +4 more
openalex +2 more sources