Order-Disorder Transitions in the Cardiac Troponin Complex. [PDF]
J Mol Biol, 2016 The troponin complex is a molecular switch that ties shifting intracellular calcium concentration to association and dissociation of actin and myosin, effectively allowing excitation-contraction coupling in striated muscle. Although there is a long history of muscle biophysics and structural biology, many of the mechanistic details that enable troponin'
Metskas LA, Rhoades E.
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Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex [PDF]
Clinical Chemistry, 2016 Abstract BACKGROUND Autoantibodies to cardiac troponins (TnAAbs) could negatively affect cardiac troponin I (cTnI) measurements by TnAAbs-sensitive immunoassays. We investigated the epitope specificity of TnAAbs and its influence on cTnI immunodetection in patients with acute myocardial infarction ...
Alexandra V Vylegzhanina +7 more
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Phosphorylation of the ‘37000 component’ of the troponin complex (troponin-T) [PDF]
Biochemical Journal, 1973 Most of the phosphorus present in the troponin complex, which on average contains 1 mol of P/80000g, is associated with the ‘37000 component’ (0.6mol of P/mol). The inhibitory protein and particularly the ‘37000 component’, but not the calcium-binding protein, were phosphorylated when incubated with phosphorylase b kinase and [γ-32P]ATP.
S V Perry, Heather Cole
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Sites of Intra- and Intermolecular Cross-linking of the N-terminal Extension of Troponin I in Human Cardiac Whole Troponin Complex [PDF]
Journal of Biological Chemistry, 2009 Our previous studies (Howarth, J. W., Meller, J., Solaro, R. J., Trewhella, J., and Rosevear, P. R. (2007) J. Mol. Biol. 373, 706–722) of the unique N-terminal region of human cardiac troponin I (hcTnI), predicted a possible intramolecular interaction ...
Chad M. Warren +2 more
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Design and Analytical Evaluation of Novel Cardiac Troponin Assays Targeting Multiple Forms of the Cardiac Troponin I–Cardiac Troponin T–Troponin C Complex and Fragmentation Forms [PDF]
Clinical ChemistryAbstract Background Current studies suggest that cardiac troponin (cTn) forms in the circulation may vary in different clinical scenarios. Our aim was to design a combination of cTn assays specific to the main cTn forms and to evaluate their analytical performance.
Ling Li +16 more
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PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis. [PDF]
PLoS ONE, 2013 AIMS:Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a potential therapeutic target, however, the exact consequences for contractile function in human ...
Viola Kooij +12 more
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Clinical Biochemistry of Serum Troponin
DiagnosticsAccurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS).
Ilhan Gokhan +8 more
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False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report [PDF]
European Heart Journal - Case Reports, 2020 Background Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease [‘classical’ myocardial ...
Z. Akhtar +5 more
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Tropomyosin-troponin complex in inherited cardiomyopathies.
Heart RhythmC. Krijger Juárez +10 more
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Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle
Cell Motility and the Cytoskeleton, 2008 Carlos Moran Segura +5 more
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