Results 11 to 20 of about 86,589 (350)
Focus on cardiac troponin complex: From gene expression to cardiomyopathy [PDF]
Genes and DiseasesThe cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin ...
Rosetta Ragusa, Chiara Caselli
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Order–Disorder Transitions in the Cardiac Troponin Complex [PDF]
Journal of Molecular Biology, 2016 The troponin complex is a molecular switch that ties shifting intracellular calcium concentration to association and dissociation of actin and myosin, effectively allowing excitation-contraction coupling in striated muscle. Although there is a long history of muscle biophysics and structural biology, many of the mechanistic details that enable troponin'
Lauren Ann Metskas, Elizabeth Rhoades
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Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases [PDF]
Animal Cells and SystemsThe troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle.
Dongju Han +3 more
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Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants. [PDF]
Journal of Biological Chemistry, 1994 Ca2+ regulation of vertebrate-striated muscle contraction is initiated by conformational changes in the Ca(2+)-binding protein troponin C (TnC) and subsequent changes in the interaction of TnC with the inhibitory protein TnI. We have constructed mutants of rabbit skeletal muscle TnC in which natural Cys-98 was replaced by Leu, and a single Cys residue ...
Tomoyoshi Kobayashi +3 more
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NMR analysis of cardiac troponin C‐troponin I complexes: effects of phosphorylation [PDF]
FEBS Letters, 1999 Phosphorylation of the cardiac specific amino‐terminus of troponin I has been demonstrated to reduce the Ca2+ affinity of the cardiac troponin C regulatory site. Recombinant N‐terminal cardiac troponin I proteins, cardiac troponin I(33–80), cardiac troponin I(1–80), cardiac troponin I(1–80)DD and cardiac troponin I(1–80)pp, phosphorylated by protein ...
Finley, Natosha +10 more
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Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. [PDF]
PLoS ONE, 2014 Cardiac troponin (cTn) is the Ca(2+)-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+) signal received at cardiac troponin C (cTnC) is ...
Jayant James Jayasundar +4 more
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Journal of Biological Chemistry, 1974 Abstract By means of new or modified procedures troponin-tropomyosin complex was fractionated into three components plus tropomyosin, and then reconstituted in the absence of urea. Tropomyosin was separated from troponin by hydroxyapatite column chromatography, a method giving sharper separation than the previously used technique of isoelectric ...
Evan Eisenberg, W. Wayne Kielley
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Calcium-dependent Changes in the Flexibility of the Regulatory Domain of Troponin C in the Troponin Complex [PDF]
Journal of Biological Chemistry, 2005 With the recent advances in structure determination of the troponin complex, it becomes even more important to understand the dynamics of its components and how they are affected by the presence or absence of Ca(2+). We used NMR techniques to study the backbone dynamics of skeletal troponin C (TnC) in the complex.
Blumenschein, Tharin M. A. +4 more
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Scientific Reports, 2023 The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic and diastolic ...
Priyanka Parijat +6 more
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Frontiers in Medicine, 2022 BackgroundChronic kidney disease has emerged as a significant independent risk factor for cardiovascular disease. Cardiovascular calcification is an active process involving a complex interaction of inducers and inhibitors.
Kamal M. Okasha +17 more
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