The calcium‐induced switch in the troponin complex probed by fluorescent mutants of troponin I [PDF]
European Journal of Biochemistry, 2003 The Ca2+‐induced transition in the troponin complex (Tn) regulates vertebrate striated muscle contraction. Tn was reconstituted with recombinant forms of troponin I (TnI) containing a single intrinsic 5‐hydroxytryptophan (5HW). Fluorescence analysis of these mutants of TnI demonstrate that the regions in TnI that respond to Ca2+ binding to the ...
Deodoro Camargo Silva Gonçalves de Oliveira +1 more
openaire +4 more sources
Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex [PDF]
Chem Biol Drug Des, 2016 W. Schlecht +3 more
semanticscholar +2 more sources
Tropomyosin–troponin complex in inherited cardiomyopathies
Heart RhythmChristian Krijger Juárez +10 more
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The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation [PDF]
BiomoleculesCardiovascular (CV) disease remains the leading cause of morbidity and mortality worldwide, highlighting the necessity of understanding its underlying molecular and pathophysiological pathways.
Mihail Celeski +11 more
doaj +2 more sources
Buffer 4-Ethylmorpholinium/Acetate: Exploring a New Alternative Buffer for Native Mass Spectrometry. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale To perform native mass spectrometry (MS) studies, there are a limited number of volatile and electrospray ionization (ESI)‐MS compatible solutions, such as ammonium bicarbonate and ammonium acetate (AA). These solutions could induce the unfolding of proteins due to the formation of CO2 bubbles or induced acidification during ESI ...
Hadavi D +8 more
europepmc +2 more sources
Cardiac Troponin I Biosensors: Innovations in Real-Time Diagnosis of Cardiovascular Diseases. [PDF]
Anal Sci AdvABSTRACT Cardiac troponin I (cTnI) is a crucial biological macromolecule found in the contractile apparatus of cardiac myocytes, exclusively expressed in cardiomyocytes. It is released into the bloodstream upon cardiac tissue injury, serving as a vital biomarker for the early detection of various heart diseases. Despite advancements in cTnI diagnostics
Ebrahimi S +7 more
europepmc +2 more sources
A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex [PDF]
Journal of Molecular and Cellular Cardiology, 2010 Ian M. Robertson +3 more
openalex +2 more sources
Troponin Variants as Markers of Skeletal Muscle Health and Diseases
Frontiers in Physiology, 2021 Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen +2 more
doaj +1 more source
An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin. [PDF]
PLoS ONE, 2013 Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD).
Gayatri Ramachandran +6 more
doaj +1 more source
Clinical Chemistry, 2022 Patient 1 was a 28-year-old Caucasian woman who presented with a 4-day history of chest pain to the same day emergency care unit at the Western General Hospital, Edinburgh, Scotland.
A. Bularga +7 more
semanticscholar +1 more source