Clinical and Translational Science, 2021 Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao +9 more
doaj +2 more sources
Construction and Interpretation of Prediction Model of Teicoplanin Trough Concentration via Machine Learning. [PDF]
Front Med (Lausanne), 2022 Objective To establish an optimal model to predict the teicoplanin trough concentrations by machine learning, and explain the feature importance in the prediction model using the SHapley Additive exPlanation (SHAP) method.
Ma P +8 more
europepmc +2 more sources
Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients. [PDF]
Front Pharmacol, 2022 Background: Linezolid is associated with myelosuppression, which may cause failure in optimally treating bacterial infections. The study aimed to define the pharmacokinetic/toxicodynamic (PK/TD) threshold for critically ill patients and to identify a ...
Wu F +11 more
europepmc +2 more sources
Pharmacology Research & Perspectives, 2021 To assess the pharmacokinetic parameters of vancomycin in Chinese critically ill pediatric patients, children treated with vancomycin, hospitalized in the intensive care unit were included.
Jihui Chen +8 more
doaj +2 more sources
Factors Affecting Voriconazole Trough Concentration and Optimal Maintenance Voriconazole Dose in Chinese Children. [PDF]
Antibiotics (Basel), 2021 Voriconazole is a triazole antifungal agent commonly used for the treatment and prevention of invasive aspergillosis (IA). However, the study of voriconazole's use in children is limited.
Zhao YC +8 more
europepmc +2 more sources
Variability of Tacrolimus Trough Concentration in Liver Transplant Patients: Which Role of Inflammation? [PDF]
Pharmaceutics, 2021 Tacrolimus presents high intra and inter-individual variability in its blood trough concentration (Cmin). Knowledge of the factors that are involved in tacrolimus Cmin variability is thus clinically important to prevent or limit it.
Anaelle Chavant +5 more
doaj +2 more sources
Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy [PDF]
Frontiers in Pharmacology, 2023 Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao +18 more
doaj +2 more sources
Therapeutic drug monitoring of tacrolimus after kidney transplantation: trough concentration or area under curve-based monitoring? [PDF]
Br J Clin PharmacolMeasurement of pre‐dose tacrolimus concentrations, also referred to as trough concentrations or C0 (in this paper the term C0 will be used), is the most frequently used parameter for therapeutic drug monitoring in patients after solid organ ...
van Gelder T +4 more
europepmc +2 more sources
Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration [PDF]
Dose-ResponseObjective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood
Lin Wang +5 more
doaj +2 more sources
Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species. [PDF]
BMC Infect Dis, 2021 Background Pharmacokinetic-pharmacodynamic (PK/PD) targets of vancomycin therapy have been recognized for methicillin-resistant Staphylococcus aureus infections but not for other gram-positive bacterial infections.
Sohn Y +15 more
europepmc +2 more sources