Results 211 to 220 of about 35,537 (259)
Some of the next articles are maybe not open access.
Current Pharmaceutical Design, 2009
Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
openaire +2 more sources
Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
openaire +2 more sources
Current Drug Target -CNS & Neurological Disorders, 2004
Noxious thermal, mechanical, or chemical stimuli evoke pain through excitation of the peripheral terminals called nociceptor, and many kinds of ionotropic and metabotropic receptors are involved in this process. Capsaicin receptor TRPV1 is a nociceptor-specific ion channel that serves as the molecular target of capsaicin.
Mitsuko, Numazaki, Makoto, Tominaga
openaire +2 more sources
Noxious thermal, mechanical, or chemical stimuli evoke pain through excitation of the peripheral terminals called nociceptor, and many kinds of ionotropic and metabotropic receptors are involved in this process. Capsaicin receptor TRPV1 is a nociceptor-specific ion channel that serves as the molecular target of capsaicin.
Mitsuko, Numazaki, Makoto, Tominaga
openaire +2 more sources
Neuroscience Bulletin, 2023
Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for mitigating brain injury after ischemic stroke. TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.
Pengyu Zong +4 more
openaire +2 more sources
Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for mitigating brain injury after ischemic stroke. TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.
Pengyu Zong +4 more
openaire +2 more sources
Comprehensive Physiology, 2012
Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
openaire +2 more sources
Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
openaire +2 more sources
2010
A wide range of single- and multi-cellular parasites infect humans and other animals, causing some of the most prevalent and debilitating diseases on the planet. There have been virtually no published studies on the TRP channels of this diverse group of organisms.
Wolstenholme AJ +2 more
openaire +3 more sources
A wide range of single- and multi-cellular parasites infect humans and other animals, causing some of the most prevalent and debilitating diseases on the planet. There have been virtually no published studies on the TRP channels of this diverse group of organisms.
Wolstenholme AJ +2 more
openaire +3 more sources
TRP channels in mechanosensation
Current Opinion in Neurobiology, 2005Channels of the TRP superfamily have sensory roles in a wide variety of receptor cells, especially in mechanosensation. In some cases, the channels appear to be directly activated by mechanical force; in others, they appear to be downstream of a messenger pathway initiated by force on a non-channel sensor.
Shuh-Yow, Lin, David P, Corey
openaire +2 more sources
Pflügers Archiv - European Journal of Physiology, 2005
The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
openaire +2 more sources
The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
openaire +2 more sources
2010
Microbes have made numerous contributions to the study of biology and medicine. Those contributions also include many original discovery's in the study of ion channels often thought as the province of neuroscientists or cardiophysiologists. Yeast have long been used as a model organism and TRP channel genes and their transmembrane products touted as ...
Marta, Kaleta, Christopher, Palmer
openaire +2 more sources
Microbes have made numerous contributions to the study of biology and medicine. Those contributions also include many original discovery's in the study of ion channels often thought as the province of neuroscientists or cardiophysiologists. Yeast have long been used as a model organism and TRP channel genes and their transmembrane products touted as ...
Marta, Kaleta, Christopher, Palmer
openaire +2 more sources
Cell Calcium, 2005
The TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: the TRPC ('Canonical') family, the TRPV ('Vanilloid') family, the TRPM ('Melastatin') family,
Pedersen, Stine Falsig +2 more
openaire +3 more sources
The TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: the TRPC ('Canonical') family, the TRPV ('Vanilloid') family, the TRPM ('Melastatin') family,
Pedersen, Stine Falsig +2 more
openaire +3 more sources
2017
The transient receptor potential (TRP) ion channels are named after the discovery of the photo-transducted channels in Drosophila. TRPs, activated by various extracellular and intracellular stimuli, play a plethora of physiological and pathological roles.
openaire +2 more sources
The transient receptor potential (TRP) ion channels are named after the discovery of the photo-transducted channels in Drosophila. TRPs, activated by various extracellular and intracellular stimuli, play a plethora of physiological and pathological roles.
openaire +2 more sources