Results 191 to 200 of about 1,264,013 (289)

Forty sites of TRP channel regulation. [PDF]

Curr Opin Chem Biol
Talyzina IA, Nadezhdin KD, Sobolevsky AI.   +2 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Correction: Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells. [PDF]

Lab Invest, 2021
Oronowicz J, Reinhard J, Reinach PS, Ludwiczak S, Luo H, Salem MHOB, Kraemer MM, Biebermann H, Kakkassery V, Mergler S.   +9 more
europepmc   +1 more source

HL-TRP channel is required for various repellents for the parthenogenetic Haemaphysalis longicornis. [PDF]

Parasit Vectors
Kuang C, Cao J, Zhou Y, Zhang H, Wang Y, Zhou J.   +5 more
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Infrared Laser Stimulation of Purkinje Cells Primarily Depends on TRP Channel Activation. [PDF]

Neurosci Bull
Dong BB, Wang C, Huang WQ, Bian YP, Liu J, Chen W, Zhou L, Shen Y, Wang L.   +8 more
europepmc   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda. [PDF]

BMC Genomics
Su H, Dai Q, Teng F, Li Z, Qi Y, Lu Y.
europepmc   +1 more source

Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells. [PDF]

Lab Invest, 2021
Oronowicz J, Reinhard J, Reinach PS, Ludwiczak S, Luo H, Omar Ba Salem MH, Kraemer MM, Biebermann H, Kakkassery V, Mergler S.   +9 more
europepmc   +1 more source