Results 181 to 190 of about 1,329,018 (250)

The TRP-channel painless mediates substrate stiffness sensing in the legs during Drosophila oviposition. [PDF]

PLoS Genet
Ray V, Bräcker LB, Kourtidis A, Rosher C, Dinges GF, Pierzchlińska A, Büschges A, Feng K, Cury KM, Gompel N.   +9 more
europepmc   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Decoding thermal adaptation: genome-wide identification of TRP channel repertoire in cephalopods and gene expression responses to chronic thermal exposure in <i>Sepia officinalis</i> and <i>Octopus maya</i> embryos. [PDF]

Front Physiol
Molina-Carrillo LM, Morini M, Dufour S, Galindo-Torres P, Ramos-Rodriguez S, Rosas C, Caamal-Monsreal C, Galindo-Sánchez CE, Schires G, Bassaglia Y, Bonnaud-Ponticelli L.   +10 more
europepmc   +1 more source

High‐resolution pressure myography reveals pressure‐dependent local contractile and geometric dynamics in the renal pelvis and ureter

British Journal of Pharmacology, EarlyView.
Background and Purpose Coordinated peristalsis between the renal pelvis and ureter is critical for effective urine transport. However, intraluminal pressure impact on upper urinary tract (UUT) contractility and pharmacologic responsiveness remains poorly understood due to absence of suitable investigative methods.
Zhugang Chu, Qidi Zhai, Liming Lu, Maik Gollasch, Dmitry Tsvetkov, Rong Dong, S. R. Wayne Chen, Gang Fan, Guangheng Luo, Mario Kassmann   +9 more
wiley   +1 more source

Forty sites of TRP channel regulation. [PDF]

Curr Opin Chem Biol
Talyzina IA, Nadezhdin KD, Sobolevsky AI.   +2 more
europepmc   +1 more source

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

m6A‐Mediated Stabilization of MRPS23 Drives NSCLC Progression Via HSPA8 and ERK Signaling Modulation

Cancer Science, EarlyView.
MRPS23 mRNA is m6A‐methylated by WTAP and stabilized by IGF2BP3, leading to increased MRPS23 protein. MRPS23 physically interacts with HSPA8, and this interaction is functionally associated with activation of the RAS–RAF–MEK–ERK pathway, ultimately promoting NSCLC cell proliferation and tumor progression.
Sihong Le, Yitao Le, Xianshen Sha, Feng Qiu, Ling Zhang   +4 more
wiley   +1 more source

Correction: Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells. [PDF]

Lab Invest, 2021
Oronowicz J, Reinhard J, Reinach PS, Ludwiczak S, Luo H, Salem MHOB, Kraemer MM, Biebermann H, Kakkassery V, Mergler S.   +9 more
europepmc   +1 more source

HL-TRP channel is required for various repellents for the parthenogenetic Haemaphysalis longicornis. [PDF]

Parasit Vectors
Kuang C, Cao J, Zhou Y, Zhang H, Wang Y, Zhou J.   +5 more
europepmc   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source