Results 181 to 190 of about 1,264,013 (289)

Gustatory avoidance of fatty acids by <i>Aedes aegypti</i> depends on an arthropod-specific TRP channel. [PDF]

Proc Natl Acad Sci U S A
Dhakal S, Bontempo AE, Singh R, Dhavan P, Montell C.   +4 more
europepmc   +1 more source

TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder. [PDF]

Front Physiol, 2021
Daugherty SL, Beckel JM, Kim KA, Freeman BA, Liu J, Wang S, de Groat WC, Zhang X.   +7 more
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

A novel TRP channel-related prognostic model of glioma based on transcriptomics and single cell sequencing analysis. [PDF]

Discov Oncol
Niu X, Guo A, Liu X, Li H, Ji H, Wang C.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Decoding thermal adaptation: genome-wide identification of TRP channel repertoire in cephalopods and gene expression responses to chronic thermal exposure in <i>Sepia officinalis</i> and <i>Octopus maya</i> embryos. [PDF]

Front Physiol
Molina-Carrillo LM, Morini M, Dufour S, Galindo-Torres P, Ramos-Rodriguez S, Rosas C, Caamal-Monsreal C, Galindo-Sánchez CE, Schires G, Bassaglia Y, Bonnaud-Ponticelli L.   +10 more
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

The TRP-channel painless mediates substrate stiffness sensing in the legs during Drosophila oviposition. [PDF]

PLoS Genet
Ray V, Bräcker LB, Kourtidis A, Rosher C, Dinges GF, Pierzchlińska A, Büschges A, Feng K, Cury KM, Gompel N.   +9 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Inhibitory Effect of Evodiamine on Psoriasis Lesions and Itching in Mice

Clinical, Cosmetic and Investigational Dermatology
Jianqiang Liang,1,* Weixiong Chen,2,* Yanhui Zhou,3 Weijia Meng,3 Man Xie,3 Yunying Weng,1 Luxuan Qin,1 Jianmin Li,4 Guanyi Wu1,5,6 1College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, People’s Republic of China; 2School ...
Liang J, Chen W, Zhou Y, Meng W, Xie M, Weng Y, Qin L, Li J, Wu G   +8 more
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