Results 171 to 180 of about 1,329,018 (250)

Comprehensive Analysis of TRP Channel-Related Genes for Estimating the Immune Microenvironment, Prognosis, and Therapeutic Effect in Patients With Esophageal Squamous Cell Carcinoma. [PDF]

Front Cell Dev Biol, 2022
Zhao F, Gao S, Qin X, Niu R, Li Z, Wang C, Li S.   +6 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

TRP channel expression patterns define molecular subtypes, prognosis, and therapeutic targets in gastric cancer. [PDF]

Front Immunol
Ding Z, Liu W, Li ZX, Cheng JQ, Deng C, Wang KW, Li LJ.   +6 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Gustatory avoidance of fatty acids by <i>Aedes aegypti</i> depends on an arthropod-specific TRP channel. [PDF]

Proc Natl Acad Sci U S A
Dhakal S, Bontempo AE, Singh R, Dhavan P, Montell C.   +4 more
europepmc   +1 more source

TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder. [PDF]

Front Physiol, 2021
Daugherty SL, Beckel JM, Kim KA, Freeman BA, Liu J, Wang S, de Groat WC, Zhang X.   +7 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

A novel TRP channel-related prognostic model of glioma based on transcriptomics and single cell sequencing analysis. [PDF]

Discov Oncol
Niu X, Guo A, Liu X, Li H, Ji H, Wang C.
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Inhibitory Effect of Evodiamine on Psoriasis Lesions and Itching in Mice

Clinical, Cosmetic and Investigational Dermatology
Jianqiang Liang,1,* Weixiong Chen,2,* Yanhui Zhou,3 Weijia Meng,3 Man Xie,3 Yunying Weng,1 Luxuan Qin,1 Jianmin Li,4 Guanyi Wu1,5,6 1College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, People’s Republic of China; 2School ...
Liang J, Chen W, Zhou Y, Meng W, Xie M, Weng Y, Qin L, Li J, Wu G   +8 more
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