Results 161 to 170 of about 1,329,018 (250)

Ecological variability of Hippopotamus antiquus from the late Early–Middle Pleistocene of Megalopolis Basin (Greece): Evidence for dynamic habitats in a glacial microrefugium

Boreas, EarlyView.
This study investigates the ecology of the extinct European Hippopotamus from the late Early–Middle Pleistocene (c. 900–400 ka) sequence of the Megalopolis Basin, a glacial microrefugium for temperate taxa in southern Greece. Using stable carbon (δ13C) and oxygen (δ18O) isotope analyses and microwear analyses of Hippopotamus dental elements, we ...
Effrosyni Roditi, Gabriele Russo, Hervé Bocherens, George E. Konidaris, Athanassios Athanassiou, Florent Rivals, Vangelis Tourloukis, Eleni Panagopoulou, Panagiotis Karkanas, Katerina Harvati   +9 more
wiley   +1 more source

TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach. [PDF]

J Comp Physiol B
Maliszewska J, Jankowska M, Artkop M, Rogalska J.   +3 more
europepmc   +1 more source

Structure and function of the calcium-selective TRP channel TRPV6. [PDF]

J Physiol, 2021
Yelshanskaya MV, Nadezhdin KD, Kurnikova MG, Sobolevsky AI.   +3 more
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

From Bibliometrics to Preliminary Clinical Evidence: TRP Channel-Mediated Neuroimmune Crosstalk in Temperature-Sensitive Airway Hyperresponsiveness. [PDF]

J Inflamm Res
Wang Y, Zhao Q, Zhang H, Wang L, Fu S, Cheng F, Qi X, Zhu X, Zhang Q, Xu D, Liu M, Zhao C.   +11 more
europepmc   +1 more source

Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal. [PDF]

Int J Mol Sci, 2021
Aleixandre-Carrera F, Engelmayer N, Ares-Suárez D, Acosta MDC, Belmonte C, Gallar J, Meseguer V, Binshtok AM.   +7 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel ...
González-Muñiz, R., García-López, M.T., Pérez de Vega, M.J., Albericio Palomera, Fernando, Fernández-Carvajal, A., Zaccaro, Laura, Royo Expósito, Miriam, Ferrer-Montiel, A.   +7 more
core  

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Visualizing insecticide control of insect TRP channel function and assembly. [PDF]

Nat Commun
Fedor JG, Kandasamy R, Park CG, Suo Y, Weisel M, Rankl NB, Nesterov A, Lee SY.   +7 more
europepmc   +1 more source