Results 161 to 170 of about 1,264,013 (289)

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca²⁺-calmodulin binding. [PDF]

J Biol Chem, 2021
Amini M, Chang Y, Wissenbach U, Flockerzi V, Schlenstedt G, Beck A.   +5 more
europepmc   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

Small, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron, Angélica Martín‐Priego, Francisco Fueyo‐González, María Mar Quesada‐Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar‐Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg, Angel Orte, Juan A. González‐Vera   +11 more
wiley   +1 more source

Advances in TRP channel drug discovery: from target validation to clinical studies. [PDF]

Nat Rev Drug Discov, 2022
Koivisto AP, Belvisi MG, Gaudet R, Szallasi A.   +3 more
europepmc   +1 more source

Self‐Assembly of Hierarchically Structured Materials From Liquid Crystalline Mesophases of Tobacco Mosaic Virus‐Like Particles

Small, EarlyView.
Recombinantly produced Tobacco Mosaic Virus coat protein (TMVcp) helical rods were demonstrated to reproducibly self‐assemble into hierarchically structured macroscopic filaments, driven by a lyotropic liquid crystal (LC) intermediate phase. The results indicate anisotropic molecular alignment of the fluid phase, retention of the native secondary ...
Guido M. Merino, Matthew J. Harrington, Amy Szuchmacher Blum   +2 more
wiley   +1 more source

Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. [PDF]

Nat Struct Mol Biol, 2021
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI.   +9 more
europepmc   +1 more source

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

, 2015
Maxim A Shevtsov,1,2 Larisa V Smagina,1 Tatiana A Kudriavtceva,3 Sergey V Petlenko,4 Irina V Voronkina1 1Institute of Cytology of the Russian Academy of Sciences (RAS), St Petersburg, Russia; 2IP Pavlov State Medical University of St  ...
Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV   +4 more
core  

Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery

Small, EarlyView.
A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee, Moo Chang Park, Sung Chan Choi, Jieun Kim, Joo‐young Kim, Jiah Lee, Hyun Jin Kim, Kyobum Kim, Yongju Kim, Woo‐jin Jeong   +9 more
wiley   +1 more source

Relationship between sensory irritation on skin surface and TRP channel activation. [PDF]

J Physiol Sci
Fujita F, Takaishi M, Iwashita S, Yoshikawa K, Sawada M, Shimizu H, Nagamatsu M, Shiomi Y, Hara T, Ishida K, Uchida K, Suzuki Y, Tominaga M.   +12 more
europepmc   +1 more source

Structure and function of the calcium-selective TRP channel TRPV6. [PDF]

J Physiol, 2021
Yelshanskaya MV, Nadezhdin KD, Kurnikova MG, Sobolevsky AI.   +3 more
europepmc   +1 more source