Results 81 to 90 of about 1,264,013 (289)

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

Angewandte Chemie, EarlyView.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong, Victor Dubois, Jamie Y. Lam, Yitzhak Tor   +3 more
wiley   +2 more sources

Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

BMC Genomics, 2006
Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana, Bisping Frederike, Kunert-Keil Christiane, Brinkmeier Heinrich   +3 more
doaj   +1 more source

Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans.

PLoS ONE, 2022
Ultrasound has been shown to affect the function of both neurons and non-neuronal cells, but, the underlying molecular machinery has been poorly understood. Here, we show that at least two mechanosensitive proteins act together to generate C.
Uri Magaram, Connor Weiss, Aditya Vasan, Kirthi C Reddy, James Friend, Sreekanth H Chalasani   +5 more
doaj   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Axial Boron Coordination Reconstructs Stereostructure of Cu Single‐Atom Nanozymes for Efficient Water‐Phase Chemical Sensing

Angewandte Chemie, EarlyView.
Sun et al. proposed an axial boron coordination strategy to reconstruct the stereostructure of Cu SAzymes and enable them to serve as efficient laccase mimics for high‐throughput smart sensor array detection of phenolic pollutants in water phases. ABSTRACT Developing single‐atom nanozymes with stereoconfigurations is a new paradigm for biomimetic ...
Qijun Sun, Hongyu Shi, Si Liu, Ziping Li, Yu Yang, Fengwang Li, Wenli Wu, Qiongzheng Hu, Kang Liang   +8 more
wiley   +2 more sources

Identification and analysis of cation channel homologues in human pathogenic fungi.

PLoS ONE, 2012
Fungi are major causes of human, animal and plant disease. Human fungal infections can be fatal, but there are limited options for therapy, and resistance to commonly used anti-fungal drugs is widespread.
David L Prole, Colin W Taylor
doaj   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Biochemical Studies of TRP Channel Activation and Modulation

, 2018
TRP channels are the cellular sensors behind many elements of somatosensation, including temperature sensing and the perception of pain. In fact, two channels, TRPV1 and TRPA1, expressed in pain-sensing nociceptor neurons, are direct molecular receptors ...
Brewster, Monique Selina Jennifer
core   +4 more sources

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications

Frontiers in Behavioral Neuroscience, 2014
Transient receptor potential (TRP) channels have attracted considerable attention because of their vital roles in primary sensory neurons, mediating responses to a wide variety of external environmental stimuli.
Shoma eSato, Toshihiro eKitamoto, Takaomi eSakai   +2 more
doaj   +1 more source