Results 91 to 100 of about 1,329,018 (250)

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

eLife, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Simon Bulley, Carlos Fernández-Peña, Raquibul Hasan, M Dennis Leo, Padmapriya Muralidharan, Charles E Mackay, Kirk W Evanson, Luiz Moreira-Junior, Alejandro Mata-Daboin, Sarah K Burris, Qian Wang, Korah P Kuruvilla, Jonathan H Jaggar   +12 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

Frontiers in Molecular Neuroscience
Epilepsy, a prevalent neurological disorder affecting millions globally, manifests as recurrent synchronous neuronal discharges that disrupt normal cerebral function.
Guolong Deng, Guolong Deng, Dayuan Liu, Dayuan Liu, Yunxiang Zhong, Yunxiang Zhong, Muyao Wang, Baoshou Su, Baoshou Su, Hongli Jiang, Hongli Jiang, Yihao Zhai, Yihao Zhai, Hao Peng, Caicai Zhang, Jigao Feng, Jigao Feng   +16 more
doaj   +1 more source

Anandamide metabolites protect against seizures through the TRP channel Water witch in Drosophila melanogaster. Jacobs et al

, 2020
Data corresponding to publication by Jack A. Jacobs and Amita Sehgal: Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster" in Cell ...
Jacobs, Jack
core   +1 more source

Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids [PDF]

, 2018
Transient receptor potential (TRP) channels represent a superfamily of unselective cation channels that are subdivided into seven subfamilies based on their sequence homology and differences in gating and functional properties.
Robert Preissner, Gohlke, B.O., Tsvetkov, D., Preissner, R., Riehle, M., Harteneck, C., Nürnberg, B., Dmitry Tsvetkov, Maik Gollasch, Gollasch, M., Christian Harteneck, Marc Riehle, Bernd Nürnberg, Björn-Oliver Gohlke   +13 more
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Anàlisi genètica i funcional de la migranya hemiplègica i la migranya comuna [PDF]

, 2011
[cat] Aquesta tesi es centra en la genètica de la migranya. La migranya comuna és un trastorn neurològic caracteritzat per episodis recurrents de mal de cap.
Carreño, Oriel
core   +3 more sources

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Mechanically Robust Thermal Insulation With High Compression Stability for Suppressing Thermal Runaway Propagation in Sodium‐Ion Battery Modules

Carbon Energy, EarlyView.
Schematics illustrate electrospun silica nanofiber fabrication, directional freezing composite assembly, and organic‐inorganic thermal crosslinking. Multiscale pore structures endow the material with robust cyclic compression resistance and low thermal conductivity.
Yin Yu, Zhiyuan Li, Guangxin Chen, Hongbo Ge, Pengjie Liu, Peiyu Duan, Huang Li, Qingsong Wang   +7 more
wiley   +1 more source