Results 111 to 120 of about 1,264,013 (289)

Mechanisms of TRP-channel mediated dopaminergic degeneration in C. elegans [PDF]

, 2014
One of the most common manifestations of dopaminergic degeneration in humans is in Parkinson’s Disease (PD). Although dopaminergic degeneration affects a significant portion of the aging population, the pathways and mechanisms underlying it have not yet ...
Popovitchenko, Tatiana
core  

The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating [PDF]

, 2015
Transient receptor potential vanilloid subtype I (TRPV1) is a thermosensory ion channel that is also gated by chemical substances such as vanilloids. Adjacent to the channel gate, this polymodal thermoTRP channel displays a TRP domain, referred to as AD1,
Valente, Pierluigi, Ferrer Montiel, Antonio, Ferrer-Montiel, Antonio, Gregorio Teruel, Lucia, Fernández-Ballester, Gregorio, Liu, Beiying, Qin, Feng, Gregorio-Teruel, Lucia, Fernández Ballester, Gregorio   +8 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms

Frontiers in Molecular Neuroscience
Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases.
Jian Huang, Aron Korsunsky, Mahdieh Yazdani, Jianhan Chen   +3 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles

BMEMat, EarlyView.
Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu, Nan Li, Yu Chen, Rui Pu, Wei Wei, Yunqi Lin, Lejing Li, Yao Lu, Jianhua Hao, Lihua Li   +9 more
wiley   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Structure and Dynamics of Porin Loops in Asymmetric Outer Membranes of E. coli

Chemistry – A European Journal, EarlyView.
What are loops of membrane proteins doing within the oligosaccharide coat of cells? This structurally unexplored space is studied by solid‐state NMR, with the outer membrane protein G (OmpG) embedded in asymmetric E. coli outer membrane (OM) vesicles as a paradigmatic example.
Morgane Adélaïde, Jayasubba Reddy Yarava, Florian Lindemann, Massilia Abbas, Nils Cremer, Lisa Gerland, Matthias Hiller, Barth van Rossum, Dirk Linke, Alexander B. Barnes, Edward P. Saliba, Özkan Yildiz, Werner Kühlbrandt, Hartmut Oschkinat   +13 more
wiley   +1 more source

Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells

Scientific Reports
Diethylcarbamazine is a classic anthelmintic that is used for the prevention and treatment of lymphatic filariasis. The mode of action of diethylcarbamazine is still not well understood with the consensus that it acts on the host immune system, rather ...
Paul D. E. Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. Martin   +3 more
doaj   +1 more source

TRP channels and breast cancer: the role of TRPs in the pathophysiological development

Frontiers in Molecular Biosciences
TRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development.
Yu Zhang, Yanfeng Yi, Yinghao Shu, Xiaochen Ru, Shuaibing He   +4 more
doaj   +1 more source