Results 121 to 130 of about 1,329,018 (250)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Mucolipin TRP cation channel 1 (MCOLN1), also called TRPML1, drives the progression of various cancers and inhibits ferroptosis in a number of diseases. This study aimed to investigate whether MCOLN1 depletion regulates ferroptosis in gastric cancer and its molecular regulatory crosstalk with the AKT pathway.
Jing Wang +5 more
wiley +1 more source
Modulatory mechanisms of nociceptive TRP channels [PDF]
, 2013 Detection of painful stimuli in the periphery is mediated by temperature-sensitive transient receptor potential (TRP) channels which are expressed in primary afferent endings of free sensory neurons called nociceptors.
Maršáková, Lenka
core
Supraglottic Botulinum Toxin Injection Improves Symptoms of Laryngeal Sensory Dysfunction
The Laryngoscope, EarlyView.In this retrospective cohort of 80 patients with refractory laryngeal sensory symptoms, supraglottic botulinum toxin type A significantly improved Laryngeal Hypersensitivity Questionnaire, Reflux Symptom Index, and Cough Severity Index scores at a mean of 5.2 weeks, while Voice Handicap Index‐10 scores remained unchanged.
Daniel Novakovic +3 more
wiley +1 more source
Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao +3 more
wiley +1 more source
Primary cilia TRP channel regulates hippocampal excitability. [PDF]
Proc Natl Acad Sci U S A, 2023 Vien TN +4 more
europepmc +1 more source
Movement Disorders, EarlyView.Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux +11 more
wiley +1 more source
Frontiers in Molecular BiosciencesBackgroundThe precise cause of ulcerative colitis (UC) is still unclear. While transient receptor potential (TRP) ion channels are increasingly linked to UC pathophysiology, the comprehensive roles of TRP channel-related genes are not well understood ...
Tiantian Bao +6 more
doaj +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain. [PDF]
Curr Biol, 2023 Liu J +5 more
europepmc +1 more source
The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease
Pediatric Investigation, EarlyView.Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia +3 more
wiley +1 more source